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Table 4 Descriptive statistics by tumor subtypes in the Swedish cohort

From: Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients

Characteristic Basal-like ERBB2 Luminal A Luminal B Normal-like p
  n = 59 n = 43 n = 122 n = 54 n = 91  
Cohort (n)       0.51e
   Stockholm 25 15 39 23 37  
   Uppsala 34 28 83 31 54  
Mean age at breast cancer diagnosis 54 59 66 61 59 <0.001e
Menopausal status (%)       0.0807e
   Premenopausal 27.5 13.3 10.9 24.4 18.6  
   Postmenopausal 72.5 86.7 89.1 75.6 78.6  
Mean tumor size (mm) 22.9 27.9 21.8 22.6 20.7 0.0345f
Tumor size < 21 mm (%) 51 35 57 42 70 <0.001e
Elston grade       <0.001e
   I 3.5 4.8 34.5 5.7 43.2  
   II 21.1 38.1 54.3 39.6 52.3  
   III 75.4 57.1 11.2 54.7 4.5  
p53 mutation (%)a 64.7 39.3 9.6 38.7 3.7 <0.001e
HRT (%)b       <0.001e
   Never 60.0 78.6 81.6 82.6 48.6  
   Former 8.0 7.1 13.2 8.7 0.0  
   Ongoing 32.0 14.3 5.3 8.7 51.4  
Lymph-positive (%) 29 48 33 41 33 0.312e
Estrogen receptor positive (%) 45.8 67.4 97.5 87.0 92.3 <0.001e
Progesterone receptor positive (%) 54.2 72.1 93.2 77.8 92.3 <0.001e
Genomically unstable (%)b 76.0 78.6 56.4 78.3 37.1 0.0031e
Genomic instability by ploidyb       0.0123e
   Diploid stable 12.0 7.1 25.6 4.3 40.0  
   Diploid unstable 4.0 0.0 20.5 26.1 17.1  
   Tetraploid stable 4.0 7.1 7.7 8.7 8.6  
   Tetraploid unstable 16.0 7.1 12.8 13.0 0.0  
   Aneuploid stable 8.0 7.1 10.3 8.7 14.3  
   Aneuploid unstable 56.0 71.4 23.1 39.1 20.0  
Treatment type (%)c       0.0353e
   None 39.7 35.7 43.3 35.8 46.2  
   Endocrine 36.2 45.2 50.8 56.6 44.0  
   Chemotherapy 15.5 16.7 5.0 5.7 7.7  
   Radiotherapy 8.6 2.4 0.8 1.9 2.2  
Breast cancer event within 5 years (%)d 30 51 17 43 19 <0.001e
  1. a p53 data were available only for the Uppsala cohort. bHRT and genomic instability were available only for the Stockholm cohort. cFor the Stockholm cohort, endocrine comprises endocrine treatment alone and with any other combination. Chemotherapy refers to chemotherapy alone or associated with radiotherapy. Radiotherapy means radiotherapy alone. dBreast cancer event refers to relapse or death for breast cancer. ePearson χ2 test. fAnalysis of variance test.