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Table 4 Descriptive statistics by tumor subtypes in the Swedish cohort

From: Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients

Characteristic

Basal-like

ERBB2

Luminal A

Luminal B

Normal-like

p

 

n = 59

n = 43

n = 122

n = 54

n = 91

 

Cohort (n)

     

0.51e

   Stockholm

25

15

39

23

37

 

   Uppsala

34

28

83

31

54

 

Mean age at breast cancer diagnosis

54

59

66

61

59

<0.001e

Menopausal status (%)

     

0.0807e

   Premenopausal

27.5

13.3

10.9

24.4

18.6

 

   Postmenopausal

72.5

86.7

89.1

75.6

78.6

 

Mean tumor size (mm)

22.9

27.9

21.8

22.6

20.7

0.0345f

Tumor size < 21 mm (%)

51

35

57

42

70

<0.001e

Elston grade

     

<0.001e

   I

3.5

4.8

34.5

5.7

43.2

 

   II

21.1

38.1

54.3

39.6

52.3

 

   III

75.4

57.1

11.2

54.7

4.5

 

p53 mutation (%)a

64.7

39.3

9.6

38.7

3.7

<0.001e

HRT (%)b

     

<0.001e

   Never

60.0

78.6

81.6

82.6

48.6

 

   Former

8.0

7.1

13.2

8.7

0.0

 

   Ongoing

32.0

14.3

5.3

8.7

51.4

 

Lymph-positive (%)

29

48

33

41

33

0.312e

Estrogen receptor positive (%)

45.8

67.4

97.5

87.0

92.3

<0.001e

Progesterone receptor positive (%)

54.2

72.1

93.2

77.8

92.3

<0.001e

Genomically unstable (%)b

76.0

78.6

56.4

78.3

37.1

0.0031e

Genomic instability by ploidyb

     

0.0123e

   Diploid stable

12.0

7.1

25.6

4.3

40.0

 

   Diploid unstable

4.0

0.0

20.5

26.1

17.1

 

   Tetraploid stable

4.0

7.1

7.7

8.7

8.6

 

   Tetraploid unstable

16.0

7.1

12.8

13.0

0.0

 

   Aneuploid stable

8.0

7.1

10.3

8.7

14.3

 

   Aneuploid unstable

56.0

71.4

23.1

39.1

20.0

 

Treatment type (%)c

     

0.0353e

   None

39.7

35.7

43.3

35.8

46.2

 

   Endocrine

36.2

45.2

50.8

56.6

44.0

 

   Chemotherapy

15.5

16.7

5.0

5.7

7.7

 

   Radiotherapy

8.6

2.4

0.8

1.9

2.2

 

Breast cancer event within 5 years (%)d

30

51

17

43

19

<0.001e

  1. a p53 data were available only for the Uppsala cohort. bHRT and genomic instability were available only for the Stockholm cohort. cFor the Stockholm cohort, endocrine comprises endocrine treatment alone and with any other combination. Chemotherapy refers to chemotherapy alone or associated with radiotherapy. Radiotherapy means radiotherapy alone. dBreast cancer event refers to relapse or death for breast cancer. ePearson χ2 test. fAnalysis of variance test.