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Table 5 Multivariate analysis of risk factors for central nervous system metastasis for the whole study population

From: Central nervous system relapse in patients with breast cancer is associated with advanced stages, with the presence of circulating occult tumor cells and with the HER2/neu status

Variable

Odds ratio

95% confidence interval

P value

Stage of disease

0.23

0.007–0.34

0.0001

Taxane-based regimen

1.61

0.71–3.63

0.246

Line of therapy

1.64

0.67–2.76

0.208

Cytokeratin 19 mRNA-positive circulating tumor cells

8.31

3.97–12.84

0.001

Premenopausal

1.9

0.58–6.45

0.278

Response to treatment

0.81

0.57–4.65

0.096

HER-2 status

29.41

7.51–101.21

0.0001

Visceral disease

1.8

0.84–3.17

0.211

  1. Dependent variable, central nervous system relapses.
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Breast Cancer Research

ISSN: 1465-542X

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