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Table 5 Multivariate analysis of risk factors for central nervous system metastasis for the whole study population

From: Central nervous system relapse in patients with breast cancer is associated with advanced stages, with the presence of circulating occult tumor cells and with the HER2/neu status

Variable Odds ratio 95% confidence interval P value
Stage of disease 0.23 0.007–0.34 0.0001
Taxane-based regimen 1.61 0.71–3.63 0.246
Line of therapy 1.64 0.67–2.76 0.208
Cytokeratin 19 mRNA-positive circulating tumor cells 8.31 3.97–12.84 0.001
Premenopausal 1.9 0.58–6.45 0.278
Response to treatment 0.81 0.57–4.65 0.096
HER-2 status 29.41 7.51–101.21 0.0001
Visceral disease 1.8 0.84–3.17 0.211
  1. Dependent variable, central nervous system relapses.