Assay design | Multiplexing capability | Throughput (no. of samples per 8 hour working day) | Cost per genotype (at maximal multiplexing)a | Type of study design that platform is suitable for | |
---|---|---|---|---|---|
TaqMan® | By manufacturer or flexible design by investigator | No | Up to 10,000+ | >US$0.30 | Small number of SNPs, large sample size |
Pyrosequencing™ | Flexible design by investigator | From 1 to 3 | Up to 4,000+ | >US$0.30 | Small number of SNPs, large sample size |
Sequenom MassARRAY® | Flexible design by investigator | From 1 to 29-plex | Up to 3,000+ | US$0.05–0.10 | Moderate number of SNPs, small/moderate sample size |
Illumina BeadArray™ (GoldenGate® Assay) | By manufacturer | From 96 to 1,536-plex | Up to 192 | <US$0.05 | Large number of SNPs, small/moderate/large sample size |
Affymetrix GeneChip® | By manufacturer | From 1,500 to 20,000-plex | Up to 16 | <US$0.05 | Large number of SNPs, small/moderate/large sample size |