Evaluation of Ki-67 proliferation and apoptotic index before, during and after neoadjuvant chemotherapy for primary breast cancer

Table 2 Logistic regression analysis showing significant associations for prediction of response by different modalities of assessment and response classifications

Response variable	p value
Pathological response (R/NR)
Ki-67 D21	0.0616
AI D21	0.0497
AI Sx	0.0620
Pathological CR
Not assessable	-
'Near' pathological CR
No significant associations	-
Clinical response (CR/PR/SD/PD)
[Path T stage T1 versus T3	0.0028]
Ki-67 D21	0.0097
AI D21	0.0224
Clinical response (CR/PR/NR)
[Path T stage T1 versus T3	0.0066]
Ki-67 D21	0.0326
AI D21	0.0224
Clinical response (R/NR)
Ki-67 D21	0.0323
Clinical CR
No significant associations	-
Radiological response (R/NR)	-
No significant associations
Mammographic response (CR/PR/SD/PD)
No significant associations	-
USS response (CR/PR/SD/PD)
No significant associations	-
Worst radiological response (CR/PR/SD/PD)
AI biopsy	0.0418
Worst radiological response (CR/PR/NR)
No significant associations	-

AI, apoptotic index; CR, complete response;D21, day-21; NR, non-responder; PD, progressive disease; PR, partial response; R, responder; SD, stable disease; USS, ultrasound scan.

ISSN: 1465-542X