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Table 2 Hazard ratios for MMP-14, MMP-2, TIMP-2 and combination of MMP-14 MMP-2 TIMP-2 on breast cancer overall survival

From: The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis

  Univariate Multivariatea Multivariateb
  HR 95% CI p value HR 95% CI p value HR 95% CI p value
MMP-14 1.31 0.99–1.72 0.05 1.36 1.03–1.81 0.031 1.18 0.87–1.59 0.28
MMP-2 1.14 0.88–1.47 0.33 1.14 0.87–1.49 0.34 0.98 0.73–1.31 0.87
TIMP-2: stromal cells 0.91 0.69–1.19 0.51 1.04 0.78–1.38 0.79 0.89 0.66–1.19 0.43
TIMP-2: cancer cells 1.07 0.83–1.39 0.61 1.09 0.83–1.43 0.53 1.02 0.77–1.34 0.91
MMP-14-/MMP-2-/TIMP-2+c 1.0    1.0      
MMP-14+/MMP-2+/TIMP-2- 1.46 0.89–2.38 0.13 1.29 0.77–2.16 0.33    
Other categories 1.11 0.76–1.63 0.59 1.03 0.68–1.55 0.90    
  1. aCox model adjusting for tumor size and number of involved lymph nodes. bCox model adjusting for tumor size, number of involved lymph nodes, HER-2/neu and urokinase plasminogen activator. cTIMP-2 by stromal cells. CI, confidence interval; HR, hazard ratio; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteases.