From: The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis
Parameter | Cases | MMP-14 | MMP-2 | TIMP-2: stromal cells | TIMP-2: cancer cells | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number | Percentage Pos | p value | Number | Pecentage Pos | p value | Number | Percentage Pos | p value | Number | Percentage Pos | p value | ||
Age years | |||||||||||||
<50 | 160 | 59 | 36.9 | 0.034 | 85 | 53.1 | 0.19 | 58 | 36.3 | 0.79 | 59 | 36.9 | 0.14 |
≥50 | 379 | 105 | 27.7 | 178 | 47.0 | 142 | 37.5 | 166 | 43.8 | ||||
Tumor size cm | |||||||||||||
<3 | 297 | 93 | 31.3 | 0.98 | 146 | 49.2 | 0.65 | 118 | 39.7 | 0.14 | 122 | 41.1 | 0.83 |
≥3 | 207 | 65 | 31.4 | 106 | 51.2 | 69 | 33.3 | 87 | 42.0 | ||||
Involved lymph nodes | |||||||||||||
0 | 190 | 46 | 24.2 | 81 | 42.6 | 71 | 37.4 | 80 | 42.1 | ||||
1 to 3 | 166 | 61 | 36.7 | 0.036 | 93 | 56.0 | 0.041 | 69 | 41.6 | 0.29 | 75 | 45.2 | 0.52 |
>3 | 174 | 54 | 31.0 | 84 | 48.3 | 58 | 33.3 | 68 | 39.1 | ||||
Peritumoral lymphovascular invasion | |||||||||||||
Yes | 143 | 50 | 35.0 | 0.15 | 76 | 53.1 | 0.097 | 50 | 35.0 | 0.15 | 64 | 44.8 | 0.027 |
No | 75 | 19 | 25.3 | 31 | 41.3 | 19 | 25.3 | 22 | 29.3 | ||||
Histological grade | |||||||||||||
I | 54 | 18 | 33.3 | 25 | 46.3 | 19 | 35.2 | 23 | 42.6 | ||||
II | 277 | 81 | 29.2 | 0.69 | 133 | 48.0 | 0.83 | 109 | 39.4 | 0.59 | 119 | 42.9 | 0.82 |
III | 197 | 64 | 32.5 | 99 | 50.3 | 69 | 35.0 | 79 | 40.1 | ||||
Nuclear grade | |||||||||||||
I | 94 | 20 | 21.3 | 40 | 42.6 | 39 | 41.5 | 42 | 44.7 | ||||
II | 307 | 98 | 31.9 | 0.066 | 158 | 51.5 | 0.27 | 105 | 34.2 | 0.22 | 128 | 41.7 | 0.79 |
III | 127 | 45 | 35.4 | 59 | 46.5 | 53 | 41.7 | 51 | 40.2 | ||||
Histological type | |||||||||||||
Invasive ductal carcinoma | 470 | 156 | 33.2 | 0.0006 | 238 | 50.6 | 0.021 | 164 | 34.9 | 0.003 | 28 | 43.1 | 0.83 |
Others | 65 | 8 | 12.3 | 23 | 35.4 | 35 | 53.8 | 196 | 41.7 | ||||
DNA ploidy | |||||||||||||
Diploid | 143 | 37 | 25.9 | 0.09 | 64 | 44.8 | 0.18 | 58 | 40.6 | 0.59 | 60 | 42.0 | 0.99 |
Non-diploid | 332 | 112 | 33.7 | 171 | 51.5 | 126 | 38.0 | 139 | 41.9 | ||||
Estrogen receptors | |||||||||||||
Negative | 143 | 53 | 37.1 | 0.055 | 76 | 53.1 | 0.22 | 59 | 41.3 | 0.25 | 61 | 42.7 | 0.89 |
Positive | 374 | 106 | 28.3 | 176 | 47.1 | 134 | 35.8 | 157 | 42.0 | ||||
Progesterone receptors | |||||||||||||
Negative | 219 | 74 | 33.8 | 0.21 | 109 | 49.8 | 0.72 | 88 | 40.2 | 0.26 | 95 | 43.4 | 0.60 |
Positive | 297 | 85 | 28.6 | 143 | 48.1 | 105 | 35.4 | 122 | 41.1 | ||||
HER-2/neu expression | |||||||||||||
Negative | 437 | 121 | 27.7 | 0.0042 | 204 | 46.7 | 0.042 | 158 | 36.2 | 0.34 | 179 | 41.0 | 0.45 |
Positive | 102 | 43 | 42.2 | 59 | 57.8 | 42 | 41.2 | 46 | 45.1 | ||||
p53 | |||||||||||||
Negative | 374 | 107 | 28.6 | 0.12 | 186 | 49.7 | 0.53 | 132 | 35.3 | 0.24 | 149 | 39.8 | 0.30 |
Positive | 152 | 54 | 35.5 | 71 | 46.7 | 62 | 40.8 | 68 | 44.7 | ||||
HSP-27 | |||||||||||||
Negative | 204 | 61 | 29.9 | 0.097 | 97 | 47.5 | 0.02 | 63 | 30.9 | 0.0024 | 70 | 34.3 | 0.0003 |
Positive | 157 | 60 | 38.2 | 94 | 59.9 | 73 | 46.5 | 84 | 53.5 | ||||
Cathepsin D cancer cells | |||||||||||||
Negative | 324 | 94 | 29.0 | 0.29 | 151 | 46.6 | 0.21 | 111 | 34.3 | 0.071 | 127 | 39.2 | 0.102 |
Positive | 207 | 69 | 33.3 | 87 | 52.2 | 87 | 42.0 | 96 | 46.4 | ||||
Cathepsin D stromal cells | |||||||||||||
Negative | 303 | 78 | 25.7 | 0.0035 | 130 | 42.9 | 0.0013 | 106 | 35.0 | 0.21 | 116 | 38.3 | 0.047 |
Positive | 226 | 85 | 37.6 | 129 | 57.1 | 91 | 40.3 | 106 | 46.9 | ||||
MMP-11 | |||||||||||||
Negative | 215 | 32 | 14.9 | <0.0001 | 65 | 30.2 | <0.0001 | 76 | 35.3 | 0.46 | 93 | 43.3 | 0.60 |
Positive | 322 | 132 | 41.0 | 198 | 61.5 | 124 | 38.5 | 132 | 41.0 | ||||
MMP-2 | |||||||||||||
Negative | 276 | 41 | 14.9 | <0.0001 | - | - | 89 | 32.2 | 0.017 | 110 | 39.9 | 0.36 | |
Positive | 263 | 123 | 46.8 | - | - | 111 | 42.2 | 115 | 43.7 | ||||
uPA | |||||||||||||
Negative | 374 | 81 | 21.7 | <0.0001 | 147 | 39.3 | <0.0001 | 127 | 34.0 | 0.016 | 143 | 38.2 | 0.017 |
Positive | 160 | 81 | 50.6 | 115 | 71.9 | 72 | 45.4 | 79 | 49.4 |