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Figure 2 | Breast Cancer Research

Figure 2

From: Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo

Figure 2

Farnesyl transferase inhibition in vitro and in vivo. (a) Detection of an unfarnesylated and a farnesylated band of the HDJ2 protein by Western blot technique on cell pellets treated with different doses of R115777 and controls. All treated cell pellets exhibit a high proportion of unfarnesylated protein. (b) Detection of an unfarnesylated and a farnesylated band of the HDJ2 protein by Western blot technique on MCF-7/HER2-18 cell tumours treated with R115777 or control vehicle. Tumours were selected from those tumours treated with R115777 exhibiting a good response and control tumours with no response on tumour growth. In four out of five treated tumours an unfarnesylated protein was detected.

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