Skip to main content
Figure 2 | Breast Cancer Research

Figure 2

From: Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo

Figure 2

Farnesyl transferase inhibition in vitro and in vivo. (a) Detection of an unfarnesylated and a farnesylated band of the HDJ2 protein by Western blot technique on cell pellets treated with different doses of R115777 and controls. All treated cell pellets exhibit a high proportion of unfarnesylated protein. (b) Detection of an unfarnesylated and a farnesylated band of the HDJ2 protein by Western blot technique on MCF-7/HER2-18 cell tumours treated with R115777 or control vehicle. Tumours were selected from those tumours treated with R115777 exhibiting a good response and control tumours with no response on tumour growth. In four out of five treated tumours an unfarnesylated protein was detected.

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us