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Figure 4 | Breast Cancer Research

Figure 4

From: Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells

Figure 4

Disrupted apico-basal polarity of IGFIR structures. Equatorial confocal sections of 20-day control (pCLXSN, panels a, c, e) and IGFIR structures (panels b, d, f) labeled with antibodies to laminin V (red; panels a, b), E-cadherin (red; panels c, d) and Golgi matrix protein of 130 kDa (GM130; green; panels e, f) and the nuclear counterstain TO-PRO-3 (blue). Arrows indicate localization of E-cadherin at cell-cell junctions (panel d) and apical localization of GM130 in control structures (panel e). Arrowheads show sites of punctate E-cadherin labeling (panel d). Scale bars = 50 μm.

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Breast Cancer Research

ISSN: 1465-542X

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