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Figure 1 | Breast Cancer Research

Figure 1

From: Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells

Figure 1

MCF-10A cells over-expressing the type I insulin-like growth factor receptor (IGFIR) form large, misshapen, filled acinar structures. (a) Differential interference contrast images of acinar structures formed from stable pools of MCF-10A cells infected with virus expressing empty vector (pCLXSN; upper panels) or wild-type IGFIR (lower panels) after 8, 15 and 20 days of growth. Scale bars = 50 μm. (b) Equatorial confocal sections of corresponding images in (a). Control (pCLXSN; upper panels) and IGFIR structures (lower panels) were labeled with the nuclear counterstain TO-PRO-3 after 8, 15 and 20 days of growth in three-dimensional culture. Scale bars = 50 μm.

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Breast Cancer Research

ISSN: 1465-542X

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