Germline polymorphisms in SIPA1are associated with metastasis and other indicators of poor prognosis in breast cancer

Table 3 Genotype distribution by tumor characteristics

SNP genotype	Disease characteristic (n [%])	Odds ratios		95% CI	P
		Crude	Adjusted^a
-313G>A (rs931127; negative/positive nodes)
GG	36 (27.5)/18 (14.5)	1.00	1.00
GA	58 (44.3)/60 (48.4)	2.23	2.15	1.14–4.06	0.0083
AA	34 (28.2)/46 (37.1)
545C>T (rs3741378; ER positive/ER negative)
CC	166 (78.7)/30 (55.6)	1.00	1.00
CT	39 (18.5)/22 (40.7)	2.95	2.90	1.52–5.48	0.0012
TT	6 (2.8)/2 (2.0)
545C>T (rs3741378; PR positive/PR negative)
CC	140 (77.8)/54 (65.1)	1.00	1.00
CT	35 (19.4)/26 (31.3)	1.88	1.86	1.05–3.30	0.0339
TT	5 (2.8)/3 (3.6)
2760G>A (rs746429; negative/positive nodes)
GG	64 (49.6)/41 (32.5)	1.00	1.00
GA	46 (35.7)/65 (51.6)	2.04	2.05	1.23–3.44	0.0062
AA	19 (14.7)/20 (20.0)

^aAdjusted analysis models include age at diagnosis. CI confidence interval; ER, estrogen receptor; progesterone receptor.

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