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Table 3 Genotype distribution by tumor characteristics

From: Germline polymorphisms in SIPA1are associated with metastasis and other indicators of poor prognosis in breast cancer

SNP genotype Disease characteristic (n [%]) Odds ratios 95% CI P
   Crude Adjusteda   
-313G>A (rs931127; negative/positive nodes)
GG 36 (27.5)/18 (14.5) 1.00 1.00   
GA 58 (44.3)/60 (48.4) 2.23 2.15 1.14–4.06 0.0083
AA 34 (28.2)/46 (37.1)     
545C>T (rs3741378; ER positive/ER negative)
CC 166 (78.7)/30 (55.6) 1.00 1.00   
CT 39 (18.5)/22 (40.7) 2.95 2.90 1.52–5.48 0.0012
TT 6 (2.8)/2 (2.0)     
545C>T (rs3741378; PR positive/PR negative)
CC 140 (77.8)/54 (65.1) 1.00 1.00   
CT 35 (19.4)/26 (31.3) 1.88 1.86 1.05–3.30 0.0339
TT 5 (2.8)/3 (3.6)     
2760G>A (rs746429; negative/positive nodes)
GG 64 (49.6)/41 (32.5) 1.00 1.00   
GA 46 (35.7)/65 (51.6) 2.04 2.05 1.23–3.44 0.0062
AA 19 (14.7)/20 (20.0)     
  1. aAdjusted analysis models include age at diagnosis. CI confidence interval; ER, estrogen receptor; progesterone receptor.