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Table 2 Participant characteristics by localized and regional/metastatic disease

From: Germline polymorphisms in SIPA1are associated with metastasis and other indicators of poor prognosis in breast cancer

Characteristic

Localized (n = 148)

Regional/metastatic (n = 152)

P

Age at diagnosis

<50 years

44 (30.1%)

57 (37.0%)

0.0042a

 

≥50 years

102 (69.9%)

97 (63.0%)

 
 

Mean age (years; mean ± SD)

59.7 ± 14.3

55.2 ± 12.6

 
 

Range (years)

33–91

25–87

 

ER status

Positive

109 (74.7%)

105 (68.2%)

0.1741b

 

Negative

22 (15.0%)

33 (21.4%)

 
 

Unknown

15 (10.3%)

16 (10.4%)

 

PR status

Positive

96 (65.7%)

87 (56.5%)

0.0489b

 

Negative

33 (22.7%)

451 (33.1%)

 
 

Unknown

17 (11.6%)

16 (10.4%)

 

Tumor size

< 2 cm

102 (69.9%)

55 (35.7%)

<0.0001c

 

≥ 2 cm

34 (27.4%)

84 (54.6%)

 
 

Unknown

4 (2.7%)

15 (9.7%)

 
 

Mean size (cm; mean ± SD)

1.6 ± 1.0

3.1 ± 2.7

 
 

Range (cm)

0.1–6.5

0.4–18.0

 

Grade

Well to moderate

86 (58.9%)

46 (29.9%)

<0.0001b

 

Poor

26 (17.8%)

79 (51.3%)

 
 

Unknown

34 (23.3%)

29 (18.8%)

 
  1. Values are expressed as n (%), unless otherwise stated. aBased on a t-test. bBased on a Fisher's exact test excluding the missing values. cBased on a t-test on the logarithmic scale. ER, estrogen receptor; PR, progesterone receptor; SD, standard deviation.