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Table 2 Participant characteristics by localized and regional/metastatic disease

From: Germline polymorphisms in SIPA1are associated with metastasis and other indicators of poor prognosis in breast cancer

Characteristic Localized (n = 148) Regional/metastatic (n = 152) P
Age at diagnosis <50 years 44 (30.1%) 57 (37.0%) 0.0042a
  ≥50 years 102 (69.9%) 97 (63.0%)  
  Mean age (years; mean ± SD) 59.7 ± 14.3 55.2 ± 12.6  
  Range (years) 33–91 25–87  
ER status Positive 109 (74.7%) 105 (68.2%) 0.1741b
  Negative 22 (15.0%) 33 (21.4%)  
  Unknown 15 (10.3%) 16 (10.4%)  
PR status Positive 96 (65.7%) 87 (56.5%) 0.0489b
  Negative 33 (22.7%) 451 (33.1%)  
  Unknown 17 (11.6%) 16 (10.4%)  
Tumor size < 2 cm 102 (69.9%) 55 (35.7%) <0.0001c
  ≥ 2 cm 34 (27.4%) 84 (54.6%)  
  Unknown 4 (2.7%) 15 (9.7%)  
  Mean size (cm; mean ± SD) 1.6 ± 1.0 3.1 ± 2.7  
  Range (cm) 0.1–6.5 0.4–18.0  
Grade Well to moderate 86 (58.9%) 46 (29.9%) <0.0001b
  Poor 26 (17.8%) 79 (51.3%)  
  Unknown 34 (23.3%) 29 (18.8%)  
  1. Values are expressed as n (%), unless otherwise stated. aBased on a t-test. bBased on a Fisher's exact test excluding the missing values. cBased on a t-test on the logarithmic scale. ER, estrogen receptor; PR, progesterone receptor; SD, standard deviation.