Spontaneous and therapeutic abortions and the risk of breast cancer among BRCAmutation carriers

Breast Cancer Research

Table 5 Therapeutic abortions among affected and unaffected BRCA mutation carriers

Number of therapeutic abortions	Cases	Controls	OR(95% CI)	P value
BRCA1 carriers
Never	1,120	1,109	1
Ever	192	202	0.98 (0.78–1.22)	0.84
1	137	144	0.97 (0.75–1.26)	0.82
2+	55	58	1.00 (0.68–1.47)	0.99
Mean	0.21	0.22		0.68
BRCA2 carriers
Never	329	308	1
Ever	51	72	0.64 (0.41–1.00)	0.05
1	39	44	0.77 (0.47–1.25)	0.29
2+	12	28	0.36 (0.16–0.83)	0.02
Mean	0.17	0.29		0.005

Odds ratios adjusted for age at menarche (years), parity (0, 1, 2, 3, 4+), age of first birth (years), oral contraceptive use (ever/never) and oophorectomy (ever/never).

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