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Table 3 Comparison of case and control subjects with BRCA1 and BRCA2 mutationsa

From: Spontaneous and therapeutic abortions and the risk of breast cancer among BRCAmutation carriers

Variable

Case subjects (N = 1,694)

Control subjects (N = 1,694)

P value

Current age (mean)

49.3

48.6

0.22

Year of birth (mean year)

1951.2

1951.8

0.10

Mutation, N (%)

   BRCA1

1,313 (77.5%)

1,313 (77.5%)

 

   BRCA2

380 (22.4%)

380 (22.4%)

 

Country of residence, N (%)

   United States

591 (34.9%)

591 (34.9%)

 

   Canada (excluding Quebec)

491 (29.0%)

491 (29.1%)

 

   Poland

439 (25.9%)

439 (25.9%)

 

   Israel

102 (6.0%)

102 (6.0%)

 

   Norway

55 (3.2%)

55 (3.2%)

 

   Sweden

7 (0.4%)

7 (0.4%)

 

   United Kingdom

6 (0.4%)

6 (0.4%)

 

   Austria

1 (0.1%)

1 (0.1%)

 

   Italy

2 (0.1%)

2 (0.1%)

 

Parityb, mean

2.2

2.2

 

Oophorectomy

61 (3.6%)

109 (6.4%)

0.0002

Oral contraceptive use, N (%)

   Ever

1,002 (59.8%)

1,009 (60.1%)

0.89

Age at menarche, mean

12.9

13.0

0.001

  1. aParity, miscarriages, and therapeutic abortions were censored one year prior to the breast cancer diagnosis of the case. Data for age at menarche, parity and therapeutic abortions are missing for a few study subjects. bParity includes live born and still born only, and was included in analysis only if birth was one calendar year before the age of diagnosis of the matched case.