Ā | Clodronate | Placebo |
---|---|---|
Total number of patients | 530 | 539 |
Skeletal-related event | Ā | Ā |
āāāConfirmed bone metastases | 51 (9.6%) % of bone | 73 (13.5%) % of bone |
āāāRadiation therapy | 24 (4.5%) (48%) | 47 (8.7%) (69%) |
āāāNon-vertebral fracture | 6 (1.1%) (2%) | 16 (2.9%) (22%) |
āāāVertebral fracture | 6 (1.1%) (2%) | 14 (2.6%) (19%) |
āāāHypercalcemia | 3 (0.5%) (1%) | 11 (2.0%) (15%) |
āāāSpinal cord compression | 2 (0.4%) (1%) | 5 (0.9%) (7%) |
āāāBone surgery | 1 (0.2%) (1%) | 4 (0.7%) (5%) |
Overall for 5 year study period1 (any skeletal event) | 29 (5.5%) (0.4%) | 53 (9.8%) (73%) |