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Table 3 Skeletal-related events in patients developing bone metastases during the five year study period

From: Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]

  Clodronate Placebo
Total number of patients 530 539
Skeletal-related event   
   Confirmed bone metastases 51 (9.6%) % of bone 73 (13.5%) % of bone
   Radiation therapy 24 (4.5%) (48%) 47 (8.7%) (69%)
   Non-vertebral fracture 6 (1.1%) (2%) 16 (2.9%) (22%)
   Vertebral fracture 6 (1.1%) (2%) 14 (2.6%) (19%)
   Hypercalcemia 3 (0.5%) (1%) 11 (2.0%) (15%)
   Spinal cord compression 2 (0.4%) (1%) 5 (0.9%) (7%)
   Bone surgery 1 (0.2%) (1%) 4 (0.7%) (5%)
Overall for 5 year study period1 (any skeletal event) 29 (5.5%) (0.4%) 53 (9.8%) (73%)
  1. 1P < 0.01 versus placebo.