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Table 3 Various breast cancer risk factors and risk of ductal, lobular and tubular breast cancer

From: Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: a case-control study

 

Controls

Ductal cancer

Lobular cancer

Tubular cancer

 

No.

No.

ORa (95%CI)

 

ORa (95%CI)

No.

ORa (95%CI)

Factor

       

Parous

       

   Nulliparous

337

292

1.0 (Ref)

40

1.0 (Ref)

10

1.0 (Ref)

   Parous

2,643

1,561

0.7 (0.6–0.8)

258

0.8 (0.6–1.2)

81

1.0 (0.5–2.0)

No of birthsb

       

   1

558

416

1.0 (Ref)

47

1.0 (Ref)

21

1.0 (Ref)

   2

1073

690

0.9 (0.7–1.0)

126

1.5c (1.0–2.1)

36

0.9 (0.5–1.6)

   3

630

318

0.7 (0.6–0.9)

58

1.3c (0.8–1.9)

19

0.9 (0.5–1.8)

   ≥4

382

137

0.6 (0.4–0.7)

27

1.1c (0.7–1.9)

5

0.5 (0.2–1.3)

Age at first birth (years)b

       

   <20

305

143

0.9 (0.7–1.1)

20

0.7 (0.4–1.1)

9

1.3 (0.6–2.9)

   20–24

1,125

600

1.0 (Ref)

106

1.0 (Ref)

25

1.0 (Ref)

   25–29

836

526

1.1 (1.0–1.3)

79

1.0 (0.7–1.4)

29

1.5 (0.9–2.6)

   ≥30

377

292

1.3 (1.1–1.6)

53

1.6 (1.1–2.3)

18

1.9 (1.0–3.7)

Age at menarche (years)d

       

   <12

164

134

1.3 (1.0–1.7)

23

1.3 (0.8–2.1)

4

0.7 (0.2–1.9)

   12–13

1,155

702

1.0 (Ref)

117

1.0 (Ref)

38

1.0 (Ref)

   14–15

1,161

723

1.1 (0.9–1.2)

109

1.0 (0.7–1.3)

43

1.2 (0.7–1.8)

   ≥16

236

113

0.8 (0.6–1.0)

23

1.0 (0.6–1.5)

3

0.4 (0.1–1.2)

Age at menopause (years)e

       

   <45

328

144

0.7 (0.5–0.8)

22

0.7 (0.4–1.1)

4

0.4 (0.1–1.1)

   45–49

658

368

0.8 (0.7–1.0)

68

1.0 (0.8–1.4)

24

1.2 (0.7–2.0)

   50–54

1,236

805

1.0 (Ref)

121

1.0 (Ref)

37

1.0 (Ref)

   ≥55

268

174

1.0 (0.8–1.3)

27

1.1 (0.7–1.7)

3

0.4 (0.1–1.2)

Height (cm)

       

   <160

652

361

1.0 (Ref)

46

1.0 (Ref)

16

1.0 (Ref)

   160–164

1,012

593

1.0 (0.9–1.2)

110

1.5c (1.1–2.2)

27

1.0 (0.5–1.8)

   165–169

880

555

1.1 (0.9–1.3)

86

1.3 (0.9–1.9)

27

1.1 (0.6–2.1)

   ≥170

436

344

1.3 (1.1–1.6)

57

1.7 (1.1–2.6)

21

1.7 (0.9–3.3)

Recent BMI (kg/m2)f

       

   <22.2

430

165

1.0 (Ref)

26

1.0 (Ref)

9

1.0 (Ref)

   22.2–<24.2

423

214

1.3 (1.0–1.7)

25

1.0 (0.6–1.7)

10

1.1 (0.4–2.8)

   24.2–<26.0

427

217

1.3 (1.0–1.7)

21

0.8 (0.5–1.5)

9

1.0 (0.4–2.5)

   26.0–<28.5

420

251

1.6 (1.2–2.0)

39

1.6 (0.9–2.6)

9

1.0 (0.4–2.6)

   ≥28..5

430

301

1.9 (1.5–2.3)

41

1.6 (1.0–2.6)

9

1.0 (0.4–2.6)

Adult weight gain (kg)d,f,g

       

   <0

159

64

0.8 (0.6–1.1)

11

0.9 (0.5–1.9)

4

0.8 (0.3–2.4)

   0–9.5

459

242

1.0 (Ref)

34

1.0 (Ref)

15

1.0 (Ref)

   10–19.5

534

349

1.2 (1.0–1.5)

44

1.1 (0.7–1.8)

13

0.7 (0.3–1.6)

   20–29.5

226

171

1.5 (1.1–1.9)

21

1.2 (0.7–2.2)

6

0.8 (0.3–2.2)

   ≥30

99

75

1.5 (1.1–2.1)

13

1.8 (0.9–3.5)

6

2.0 (0.7–5.3)

Mother or sister with breast cancerd

       

   No

2,294

1,530

1.0 (Ref)

237

1.0 (Ref)

73

1.0 (Ref)

   Yes

233

278

1.8 (1.5–2.2)

57

2.4 (1.8–3.4)

15

2.2 (1.2–3.9)

Operated due to benign breast diseased

       

   No

2,315

1,590

1.0 (Ref)

245

1.0 (Ref)

82

1.0 (Ref)

   Yes

242

253

1.5 (1.2–1.8)

53

1.9 (1.4–2.6)

9

0.9 (0.4–1.8)

Oral contraceptive used

       

   No use

2,030

1,237

1.0 (Ref)

198

1.0 (Ref)

55

1.0 (Ref)

   Duration

       

<5 years

470

302

0.9 (0.7–1.0)

40

0.6 (0.4–0.9)

23

1.3 (0.7–2.2)

≥5 years

331

215

0.9 (0.7–1.1)

42

0.9 (0.6–1.4)

13

1.0 (0.5–1.9)

Recent alcohol consumption (g/day)d

       

   No alcohol

1,108

762

1.0 (Ref)

111

1.0 (Ref)

28

1.0 (Ref)

   <5

905

674

1.0 (0.9–1.2)

101

1.0 (0.8–1.4)

34

1.2 (0.7–2.1)

   ≥5–10

210

171

1.1 (0.9–1.4)

32

1.3 (0.9–2.1)

12

1.8 (0.9–3.6)

   >10

100

72

1.0 (0.7–1.4)

19

1.6 (0.9–2.8)

10

3.1c (1.4–6.8)

Recent smokingd

       

   No

2,212

1,442

1.0 (Ref)

229

1.0 (Ref)

63

1.0 (Ref)

   Yes

696

408

1.2 (1.0–1.4)

68

1.1 (0.8–1.5)

28

0.8c (0.5–1.2)

  1. Recent = one year before data collection. aAdjusted for age, and where applicable also for estrogen-progestin use (ever/never). bNumber of births and age at first birth were adjusted for each other. cStatistically significant difference compared with the estimate for ductal cancer. dSome cases and controls excluded due to missing information. eWomen with unknown age at menopause and women using menopausal hormone therapy apart from local estrogen before menopause excluded. fWomen ever menopausal hormone therapy apart from local estrogen excluded. gWeight gain from 18 years of age to one year before data collection. BMI, body mass index; CI, confidence interval; OR, odds ratio; Ref, reference category.
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Breast Cancer Research

ISSN: 1465-542X

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