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Table 3 Various breast cancer risk factors and risk of ductal, lobular and tubular breast cancer

From: Menopausal hormone therapy and other breast cancer risk factors in relation to the risk of different histological subtypes of breast cancer: a case-control study

  Controls Ductal cancer Lobular cancer Tubular cancer
  No. No. ORa (95%CI)   ORa (95%CI) No. ORa (95%CI)
Factor        
Parous        
   Nulliparous 337 292 1.0 (Ref) 40 1.0 (Ref) 10 1.0 (Ref)
   Parous 2,643 1,561 0.7 (0.6–0.8) 258 0.8 (0.6–1.2) 81 1.0 (0.5–2.0)
No of birthsb        
   1 558 416 1.0 (Ref) 47 1.0 (Ref) 21 1.0 (Ref)
   2 1073 690 0.9 (0.7–1.0) 126 1.5c (1.0–2.1) 36 0.9 (0.5–1.6)
   3 630 318 0.7 (0.6–0.9) 58 1.3c (0.8–1.9) 19 0.9 (0.5–1.8)
   ≥4 382 137 0.6 (0.4–0.7) 27 1.1c (0.7–1.9) 5 0.5 (0.2–1.3)
Age at first birth (years)b        
   <20 305 143 0.9 (0.7–1.1) 20 0.7 (0.4–1.1) 9 1.3 (0.6–2.9)
   20–24 1,125 600 1.0 (Ref) 106 1.0 (Ref) 25 1.0 (Ref)
   25–29 836 526 1.1 (1.0–1.3) 79 1.0 (0.7–1.4) 29 1.5 (0.9–2.6)
   ≥30 377 292 1.3 (1.1–1.6) 53 1.6 (1.1–2.3) 18 1.9 (1.0–3.7)
Age at menarche (years)d        
   <12 164 134 1.3 (1.0–1.7) 23 1.3 (0.8–2.1) 4 0.7 (0.2–1.9)
   12–13 1,155 702 1.0 (Ref) 117 1.0 (Ref) 38 1.0 (Ref)
   14–15 1,161 723 1.1 (0.9–1.2) 109 1.0 (0.7–1.3) 43 1.2 (0.7–1.8)
   ≥16 236 113 0.8 (0.6–1.0) 23 1.0 (0.6–1.5) 3 0.4 (0.1–1.2)
Age at menopause (years)e        
   <45 328 144 0.7 (0.5–0.8) 22 0.7 (0.4–1.1) 4 0.4 (0.1–1.1)
   45–49 658 368 0.8 (0.7–1.0) 68 1.0 (0.8–1.4) 24 1.2 (0.7–2.0)
   50–54 1,236 805 1.0 (Ref) 121 1.0 (Ref) 37 1.0 (Ref)
   ≥55 268 174 1.0 (0.8–1.3) 27 1.1 (0.7–1.7) 3 0.4 (0.1–1.2)
Height (cm)        
   <160 652 361 1.0 (Ref) 46 1.0 (Ref) 16 1.0 (Ref)
   160–164 1,012 593 1.0 (0.9–1.2) 110 1.5c (1.1–2.2) 27 1.0 (0.5–1.8)
   165–169 880 555 1.1 (0.9–1.3) 86 1.3 (0.9–1.9) 27 1.1 (0.6–2.1)
   ≥170 436 344 1.3 (1.1–1.6) 57 1.7 (1.1–2.6) 21 1.7 (0.9–3.3)
Recent BMI (kg/m2)f        
   <22.2 430 165 1.0 (Ref) 26 1.0 (Ref) 9 1.0 (Ref)
   22.2–<24.2 423 214 1.3 (1.0–1.7) 25 1.0 (0.6–1.7) 10 1.1 (0.4–2.8)
   24.2–<26.0 427 217 1.3 (1.0–1.7) 21 0.8 (0.5–1.5) 9 1.0 (0.4–2.5)
   26.0–<28.5 420 251 1.6 (1.2–2.0) 39 1.6 (0.9–2.6) 9 1.0 (0.4–2.6)
   ≥28..5 430 301 1.9 (1.5–2.3) 41 1.6 (1.0–2.6) 9 1.0 (0.4–2.6)
Adult weight gain (kg)d,f,g        
   <0 159 64 0.8 (0.6–1.1) 11 0.9 (0.5–1.9) 4 0.8 (0.3–2.4)
   0–9.5 459 242 1.0 (Ref) 34 1.0 (Ref) 15 1.0 (Ref)
   10–19.5 534 349 1.2 (1.0–1.5) 44 1.1 (0.7–1.8) 13 0.7 (0.3–1.6)
   20–29.5 226 171 1.5 (1.1–1.9) 21 1.2 (0.7–2.2) 6 0.8 (0.3–2.2)
   ≥30 99 75 1.5 (1.1–2.1) 13 1.8 (0.9–3.5) 6 2.0 (0.7–5.3)
Mother or sister with breast cancerd        
   No 2,294 1,530 1.0 (Ref) 237 1.0 (Ref) 73 1.0 (Ref)
   Yes 233 278 1.8 (1.5–2.2) 57 2.4 (1.8–3.4) 15 2.2 (1.2–3.9)
Operated due to benign breast diseased        
   No 2,315 1,590 1.0 (Ref) 245 1.0 (Ref) 82 1.0 (Ref)
   Yes 242 253 1.5 (1.2–1.8) 53 1.9 (1.4–2.6) 9 0.9 (0.4–1.8)
Oral contraceptive used        
   No use 2,030 1,237 1.0 (Ref) 198 1.0 (Ref) 55 1.0 (Ref)
   Duration        
<5 years 470 302 0.9 (0.7–1.0) 40 0.6 (0.4–0.9) 23 1.3 (0.7–2.2)
≥5 years 331 215 0.9 (0.7–1.1) 42 0.9 (0.6–1.4) 13 1.0 (0.5–1.9)
Recent alcohol consumption (g/day)d        
   No alcohol 1,108 762 1.0 (Ref) 111 1.0 (Ref) 28 1.0 (Ref)
   <5 905 674 1.0 (0.9–1.2) 101 1.0 (0.8–1.4) 34 1.2 (0.7–2.1)
   ≥5–10 210 171 1.1 (0.9–1.4) 32 1.3 (0.9–2.1) 12 1.8 (0.9–3.6)
   >10 100 72 1.0 (0.7–1.4) 19 1.6 (0.9–2.8) 10 3.1c (1.4–6.8)
Recent smokingd        
   No 2,212 1,442 1.0 (Ref) 229 1.0 (Ref) 63 1.0 (Ref)
   Yes 696 408 1.2 (1.0–1.4) 68 1.1 (0.8–1.5) 28 0.8c (0.5–1.2)
  1. Recent = one year before data collection. aAdjusted for age, and where applicable also for estrogen-progestin use (ever/never). bNumber of births and age at first birth were adjusted for each other. cStatistically significant difference compared with the estimate for ductal cancer. dSome cases and controls excluded due to missing information. eWomen with unknown age at menopause and women using menopausal hormone therapy apart from local estrogen before menopause excluded. fWomen ever menopausal hormone therapy apart from local estrogen excluded. gWeight gain from 18 years of age to one year before data collection. BMI, body mass index; CI, confidence interval; OR, odds ratio; Ref, reference category.