Recent translational research: Oncogene discovery by insertional mutagenesis gets a new boost

Breast Cancer Research

Table 1 Oncogenes and candidate oncogenes detected by MMTV insertional mutagenesis in mouse mammary tumours

Gene	Gene product	Confirmed oncogenicity	Evidence for involvement in human breast cancer	Reference
Fgf3/int2	Fibroblast growth factor	Yes	No	[22]
Fgf4	Fibroblast growth factor	Yes	No	[23]
Fgf8	Fibroblast growth factor	Yes	Yes	[24]
Fgf10	Fibroblast growth factor	Yes	Yes	[11]
Int-5IInt-H	Aromatase	Yes	Yes	[25]
Int6/Eif3e	Translation initiation factor 3 subunit	Yes	No	[26]
Int7	Thrombospondin domain containing gene	No	No	[12]
Int-41	Unknown	No	No	[27]
Map3k8/Tpl2	Mitogen-activated protein kinase	Yes	Yes	[28]
Notch1	Receptor/transcription cofactor precursor	Yes	Yes	[29]
Notch4/Int3	Receptor/transcription cofactor precursor	Yes	No	[30]
Wnt/int1	Morphogen	Yes	No	[2]
Wnt3	Morphogen	Yes	No	[31]
Wnt10b	Morphogen	Yes	Yes	[32]

ISSN: 1465-542X