Breast Cancer Research

Table 2 Components of the epidermal growth factor receptor pathway affected by copy number change

From: Comprehensive copy number profiles of breast cancer cell model genomes

Gene	Locus	MCF-7	BT-474	ZR-75-30	UACC-893	Sk-Br-3	MDA-MB-231	T47D
EGF	4q25					+
TGFA	2p13.3		-			-
NRG2	5q31.2					+
NRG1	8p12	--		--	-
EGFR	7p12.3-p12.1		+			+
ErBB2	17q12		+++	+++	+++	+++
ErBB3	12q13
ErBB4	2q33.3-q34
SH3KBP1	Xp22.12	--
RASA2	3q23		+					+
VAV2	9q34.2	+	+	-
GRB2	17q25.1	++			+++
PLCG1	20q12	+++	-				+	+
PLCG2	16q23.2			-		-		+
RNTRE	10p14							+
SSH3BP1	10p12.1				+
SOS1	2p22.1		-	-
PTK2B	8p21.2	-	-	--	--
SRC	20q11.23		--			+++	++
NRAS	1p13.2	+++			-
CDC42	1p36.12		-
RAC1	7p22.1					+
RIN1	11q13.2		+
RAF1	3p25.2	+						+
MAP3K4	6q26	--	-
MAP3K11	11q13.1	+	+++
PAK1	11q13.5							+
ADAM9	8p11.23							+
ADAM12	10q26.2		---		-
ADAM17	2p25.1		+
RAB5a	3p24.3					+
MAP2K1	15q21	-
MAP2K7	19p13.2			-
MAP2K4	17q11.2			--	--
MAP2K3	17p11.2			-	-	-
MAP2K6	17q24.3		+++			+		+
PDPK1	16p13.3		+
CHN2	7p15.1		+		+	++		+
PRKCA	17q24.2	+++	++			+		+
ERK1	16p11.2	+
ERK2	22q11.21					-
MAPK8	10q11.22							+
MAPK9	5q35.3		-	-
MAPK14	6p21.31						++
AKT1	14q32.33	+	+					+
BAD	11q13.1		+++
LIMK1	7q11.23		+	+++		+++		+
PLD1	3q26.31					+		++
RPS6KA3	Xp22.12	-
FOS	14q24.3	+
JUN	1p32-p31	-
TP53	17p13.1		+	--				-
MYC	8q24	+++	++	+++	+	+++		+
ELK1	Xp11.23	-	-		+
JUN	1p32.1	-
EGF	4q25					+

Scores: +, log₂ ratio +0.4 to +0.7; ++, log₂ ratio +0.7 to +0.99; +++, log₂ ratio more than +1.0; -, log₂ ratio -0.4 to -0.7; --, log₂ ratio -0.7 to -0.99; ---, log₂ ratio less than -1.0.

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