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Table 1 Changes in receptors and growth with menopausal status

From: Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer

Marker

Age ≤50 years (mean ± SEM)

Age >50 years (mean ± SEM)

P value

ER-α-TDLUa

2.65 ± 0.06 (n = 342)

3.62 ± 0.06 (n = 273)

<0.0001

ER-α-HELUa

4.37 ± 0.07 (n = 201)

4.66 ± 0.07 (n = 197)

0.013

PR-TDLUa

2.15 ± 0.09 (n = 383)

2.01 ± 0.10 (n = 264)

0.08

PR-HELUa

3.58 ± 0.10 (n = 274)

3.34 ± 0.10 (n = 236)

0.02

Ki67-TDLU

2.52 ± 0.67 (n = 106)

1.38 ± 0.69 (n = 95)

0.024

Ki67-HELU

7.32 ± 0.74 (n = 67)

5.11 ± 0.73 (n = 69)

0.017

TUNEL-TDLU

0.80 ± 0.06% (n = 234)

0.43 ± 0.07% (n = 142)

<0.0001

TUNEL-HELU

0.26 ± 0.06% (n = 215)

0.18 ± 0.07% (n = 140)

0.38

  1. This table compares average ER-α expression, PR expression, proliferation rate (Ki67), and apoptosis rate (TUNEL) between normal TDLUs and HELUs from the same breasts, stratified by age as a surrogate for menopausal/estrogen status. aAverage proportion score representing the estimated proportion of positive cells (0 = none, 1 < 1/100, 2 = 1/100 to 1/10, 3 = 1/10 to 1/3, 4 = 1/3 to 2/3, and 5 = >2/3). ER, estrogen receptor; HELU, hyperplastic enlarged lobular unit; TDLU, terminal duct lobular unit; PR, progesterone receptor; TUNEL, terminal transferase-mediated dUTP nick end-labeling.