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Table 1 Patients' characteristics

From: Reverting estrogen-receptor-negative phenotype in HER-2-overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy

Patient

Baseline evaluation

After treatment

 

ER, %

PgR, %

HER2, % (score)

First assessment

Time A

Chemotherapy

Time B

Second assessment

ER, %

PgR, %

HER2, % (score)

HT

Clinical response

1

0

0

80 (3+)

Skin

20

Paclitaxel

9

Skin

10

0

70 (3+)

No

PR

2

0

0

70 (3+)

Pleura

87

Paclitaxel

11

Pleura

0

0

75 (3+)

No

SD

3

0

0

90 (3+)

Skin

8

Nonea

4

Skin

0

0

90 (3+)

No

PR

4

0

0

40 (3+)

Skin

31

Paclitaxel

9

Skin

0

0

90 (3+)

No

PD

5

0

0

90 (3+)

Liver

5

Nonea

12

Ovary

50

40

80 (3+)

Yes

PD

6

0

0

95 (3+)

Breast

2

Paclitaxel

37

Breast

20

0

90 (3+)

Yes

PR

7

0

0

80 (3+)

Skin

64

Nonea

4

Skin

0

0

95 (3+)

No

PR

8

0

0

90 (3+)

Lung

2

Paclitaxel

4

Skin

0

0

90 (3+)

No

SD

9

0

0

80 (3+)

Skin

51

Paclitaxel

22

Skin

0

0

40 (2+)

No

PR

10

0

0

90 (3+)

Skin

17

Vinorelbine

3

Skin

0

0

90 (3+)

No

PR

  1. The table shows the evaluation of patients' characteristics at baseline with the site of disease at which the biological characteristics were evaluated, and after treatment with trastuzumab with the site of disease at which the biological characteristics were reassessed. ER, estrogen receptor; first assessment, site of disease where ER, PgR and HER2 were evaluated at baseline; HT, hormonal treatment; PgR, progesterone receptor; second assessment, site of disease where ER, PgR and HER2 were reassessed; time A, time elapsed between first assessment and treatment start (weeks); time B, time elapsed between trastuzumab start and second assessment (weeks). PD, progressive disease. SD, stable disease. PR, partial response.
  2. aPaclitaxel was introduced after progression to trastuzumab alone.