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Table 4 Estimated cumulative risks of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers

From: BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families

Age (years) BRCA1 BRCA2
  BC OC BC or OC BC OC BC or OC
30 3 0 4 0.3 0 0.4
40 13 0 14 13 0.2 26
50 20 (0–45) 1 (0–10) 23 (0–48) 21 (0–55) 0.4 (0–2) 35 (0–64)
60 71 38 83 33 49 55
70 72 (0–93) 38 (0–78) 83 (34–96) 75 (0–97) 49 (0–81) 89 (34–98)
  1. Shown are percentage cumulative risks (95% confidence interval). BC, breast cancer; OC, ovarian cancer.