|
Number of cancers, age under 70 years
|
Model
|
BRCA1
|
BRCA2
|
Noncarriers
|
|---|
| | |
Observed
|
Expected
|
Observed
|
Expected
|
Observed
|
Expected
|
|---|
|
≥3 BC, ≥1 OC
|
BOADICEA
|
| |
Full pedigrees
|
9
|
6.92
|
4
|
3.80
|
21
|
23.28
|
| |
Second-degree relatives
|
6
|
3.12
|
1
|
1.49
|
7
|
9.38
|
| |
BRCAPRO
|
6
|
7.80
|
1
|
2.35
|
7
|
3.98
|
|
≥4 BC, 0 OC
|
BOADICEA
|
| |
Full pedigrees
|
2
|
6.20
|
14
|
14.75
|
90
|
85.05
|
| |
Second-degree relatives
|
2
|
4.11
|
12
|
8.60
|
57
|
58.29
|
| |
BRCAPRO
|
2
|
19.40
|
12
|
8.27
|
57
|
43.37
|
|
3 BC, 0 OC
|
BOADICEA
|
| |
Full pedigrees
|
0
|
0.82
|
1
|
1.20
|
25
|
23.97
|
| |
Second-degree relatives
|
1
|
1.09
|
2
|
1.77
|
37
|
37.13
|
| |
BRCAPRO
|
1
|
5.43
|
2
|
2.97
|
37
|
31.60
|
|
2 BC, any OC
|
BOADICEA
|
| |
Full pedigrees
|
3
|
1.75
|
0
|
0.34
|
19
|
19.91
|
| |
Second-degree relatives
|
5
|
3.83
|
4
|
1.40
|
54
|
57.79
|
| |
BRCAPRO
|
5
|
9.53
|
4
|
2.08
|
54
|
51.50
|
- BC, breast cancer; OC, ovarian cancer.
