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Table 3 Observed and expected number of mutations among the first screened individuals by number of cancers in the family

From: BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families

Number of cancers, age under 70 years Model BRCA1 BRCA2 Noncarriers
   Observed Expected Observed Expected Observed Expected
≥3 BC, ≥1 OC BOADICEA
     Full pedigrees 9 6.92 4 3.80 21 23.28
     Second-degree relatives 6 3.12 1 1.49 7 9.38
  BRCAPRO 6 7.80 1 2.35 7 3.98
≥4 BC, 0 OC BOADICEA
     Full pedigrees 2 6.20 14 14.75 90 85.05
     Second-degree relatives 2 4.11 12 8.60 57 58.29
  BRCAPRO 2 19.40 12 8.27 57 43.37
3 BC, 0 OC BOADICEA
     Full pedigrees 0 0.82 1 1.20 25 23.97
     Second-degree relatives 1 1.09 2 1.77 37 37.13
  BRCAPRO 1 5.43 2 2.97 37 31.60
2 BC, any OC BOADICEA
     Full pedigrees 3 1.75 0 0.34 19 19.91
     Second-degree relatives 5 3.83 4 1.40 54 57.79
  BRCAPRO 5 9.53 4 2.08 54 51.50
  1. BC, breast cancer; OC, ovarian cancer.