Attributes diagram. Shown is an attributes diagram comparing the predicted carrier probabilities and the observed carrier frequencies for BRCA1 and BRCA2 mutations combined. BOADICEA predictions were carried out using data from all reported family members and restricted to second-degree relatives only. BRCAPRO predictions were adjusted for an 80% sensitivity for the mutation screening methods used. Each point represents a sextile of the data and 95% confidence intervals were computed assuming a binomial distribution.