Drug associationa
| Iban + TAM | Iban + ICI |
---|
50% CI, mean (SD) | 1.0 (0.1) | 0.9 (0.2) |
Combination effect | Additive | Additive |
75% CI, mean (SD) | 1.1 (0.1) | 1.0 (0.3) |
Combination effect | Additive | Additive |
- The 50% and 75% combination index values corresponding to drug concentrations leading to 50% and 75% cell growth, respectively, were determined by crystal violet staining assay, as detailed in Materials and methods. aExposure to ibandronate (Iban) and/or 4-hydroxytamoxifen (TAM) or ICI 182,780 (ICI) for 72 hours in three separate experiments. SD, standard deviation.