Figure 7
Effect of combined treatment of MCF-7, IBEP-2 and MDA-MB-231 cells with ibandronate (Iban) and 4-hydroxytamoxifen (TAM) or ICI 182,780 (ICI). Cells were incubated with 10-4 M Iban in the presence or absence of 10-7 M TAM or ICI for 72 hours. Cell proliferation was determined as described in Fig. 1. ANOVA, p < 0.01: a, significantly different from control; b, significantly different from Iban alone; c, significantly different from TAM alone; d, significantly different from ICI alone; Tukey post hoc test.