Table 2 Regions of high-level copy number gain
Chromosome | Region (Mb)a,b | Cell lines IR > 2 | Tumors IR > 2 | Tumors IR 1.2–2.0 | Cancer genes |
|---|---|---|---|---|---|
1 | 158.8–159.6 | 0 | 2 (4%) | 29 (61.7%) |  |
1 | 202.1 | 4 (22%) | 4 (9%) | 31 (66.0%) | KISS1 |
4 | 6.9 | 1 (6%) | 2 (4%) | 22 (46.8%) | Â |
6 | 11.2–15.6 | 0 | 2 (4%) | (%) |  |
6 | 139.6–143.6 | 0 | 2 (4%) | (%) |  |
7 | 54.4–57.1 | 2 (11%) | 2 (4%) | 12 (25.5%) | EGFR |
8 | 0.1–0.3 | 1 (6%) | 2 (4%) | 31 (66.0%) |  |
8 | 36.9–42.0 | 1 (6%) | 4 (9%) | 13 (27.7%) | WHSCIL1, FGFR |
8 | 74.0–75.1 | 1 (6%) | 2 (4%) | 11 (23.4%) |  |
8 | 123.8–127.5 | 3 (17%) | 2 (4%) | 20 (42.6%) | MYC |
8 | 139.3–144.8 | 10 (56%) | 5 (11%) | 37 (78.7%) | PTK2 |
11 | 58.8–61.3 | 0 | 3 (6%) |  |  |
11 | 66.1–71.5 | 1 (6%) | 2 (4%) |  | DDB1 |
11 | 73.4–77.5 | 1 (6%) | 2 (4%) |  | WNT11, PAK1 |
13 | 111.4–112.9 | 4 (22%) | 4 (9%) | 21 (44.7%) | GAS6 |
17 | 35.1–38.3 | 2 (11%) | 5 (11%) | 17 (36.2%) | TAF15, MLLT6, ERBB2 |
17 | 58.1–60.4 | 2 (11%) | 2 (4%) | 10 (21.3%) | PPM1D |
20 | 43.8–45.9 | 4 (22%) | 3 (6%) | 5 (10.6%) | MMP9 |
20 | 49.2–50.0 | 2 (11%) | 2 (4%) |  |  |
21 | 45.1–45.8 | 3 (17%) | 5 (11%) | 18 (38.3%) | ITGB2 |