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Table 2 Regions of high-level copy number gain

From: High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

Chromosome Region (Mb)a,b Cell lines IR > 2 Tumors IR > 2 Tumors IR 1.2–2.0 Cancer genes
1 158.8–159.6 0 2 (4%) 29 (61.7%)  
1 202.1 4 (22%) 4 (9%) 31 (66.0%) KISS1
4 6.9 1 (6%) 2 (4%) 22 (46.8%)  
6 11.2–15.6 0 2 (4%) (%)  
6 139.6–143.6 0 2 (4%) (%)  
7 54.4–57.1 2 (11%) 2 (4%) 12 (25.5%) EGFR
8 0.1–0.3 1 (6%) 2 (4%) 31 (66.0%)  
8 36.9–42.0 1 (6%) 4 (9%) 13 (27.7%) WHSCIL1, FGFR
8 74.0–75.1 1 (6%) 2 (4%) 11 (23.4%)  
8 123.8–127.5 3 (17%) 2 (4%) 20 (42.6%) MYC
8 139.3–144.8 10 (56%) 5 (11%) 37 (78.7%) PTK2
11 58.8–61.3 0 3 (6%)   
11 66.1–71.5 1 (6%) 2 (4%)   DDB1
11 73.4–77.5 1 (6%) 2 (4%)   WNT11, PAK1
13 111.4–112.9 4 (22%) 4 (9%) 21 (44.7%) GAS6
17 35.1–38.3 2 (11%) 5 (11%) 17 (36.2%) TAF15, MLLT6, ERBB2
17 58.1–60.4 2 (11%) 2 (4%) 10 (21.3%) PPM1D
20 43.8–45.9 4 (22%) 3 (6%) 5 (10.6%) MMP9
20 49.2–50.0 2 (11%) 2 (4%)   
21 45.1–45.8 3 (17%) 5 (11%) 18 (38.3%) ITGB2
  1. Regions of copy number gain containing more than one amplification with intensity ratio (IR) >2.0, as well as frequency of single copy gain (IR 1.2–2.0) in these regions. aMap positions and cytogenetic locations are based on data available from UCSC genome browser (July 2003 freeze) [35]. bRegion boundaries were determined by the next bacterial artificial chromosome with different copy number.