Effect of CCN6 inhibition on random motility and invasion. (a) A reconstituted basement membrane invasion chamber assay was used to investigate the effects of CCN6 inhibition on the invasion abilities of HME cells. Representative fields of invaded and stained cells are shown. t test *p < 0.04 vs. control. (b) Cell motility on a field of microscopic fluorescent beads. Representative photomicrographs show the clearing in the fluorescent bead field corresponding to phagokinetic cell tracks. *p < 0.005 vs. control. Experiments were performed independently three times. C1 and C2 are two stable CCN6 deficient clones.