TY - JOUR AU - Zhang, Yanhong AU - Pan, Quintin AU - Zhong, Hui AU - Merajver, Sofia D. AU - Kleer, Celina G. PY - 2005 DA - 2005/11/08 TI - Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells JO - Breast Cancer Research SP - R1080 VL - 7 IS - 6 AB - CCN6/WISP3 belongs to the CCN (Cyr61, CTGF, Nov) family of genes that contains a conserved insulin-like growth factor (IGF) binding protein motif. CCN6 is a secreted protein lost in 80% of the aggressive inflammatory breast cancers, and can decrease mammary tumor growth in vitro and in vivo. We hypothesized that inhibition of CCN6 might result in the loss of a growth regulatory function that protects mammary epithelial cells from the tumorigenic effects of growth factors, particularly IGF-1. SN - 1465-542X UR - https://doi.org/10.1186/bcr1351 DO - 10.1186/bcr1351 ID - Zhang2005 ER -