Figure 4From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanismDHEA and DHEA8354 differentially affect p16, p21, and p53 protein expression: Western blot data of control tumors (lanes 1 to 3) and tumors treated with DHEA (1,000 mg/kg diet) (lanes 4 to 6) as estimated by western blotting. For western blotting, tumors were selected with relatively high values of senescence-associated β-galactosidase (SA-β-Gal)-labelled cells and low values of bromodeoxyuridine-labeled cells.Back to article page