DHEA and DHEA8354 suppress the growth of mammary tumors. (a) Growth curves of mammary tumors in control animals. (b, c) Growth curves of mammary tumors in animals treated with dehydroepiandrosterone (DHEA) (b) or DHEA 8354 (c) (1,000 mg/kg in diet). In 50% of DHEA-treated tumors a net decrease in growth potential over control was observed, whereas with DHEA 8354 some animals showed a decrease in growth potential. Each curve represents an individual tumor.