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Table 3 Summary of associations between patient characteristics and ductal lavage cellularity

From: Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation

  ICMD ducts Cell count/ml Total cell count/specimen
  % P 1 Median Range P 2 Median Range P 2
Overall 39   600 0 to 909,090   9481 0 to 21,818,160  
FY Status         
   FY duct 32   1625 0 to 909,090   30,996 0 to 21,818,160  
   Non-FY duct 57 0.037 0 0 to 4959 <0.001 0 0 to 173,577 0.002
Menopausal status         
   Premenopausal 28   1000 0 to 50,000   22,000 0 to 600,000  
   Postmenopausal 51 0.034 0 0 to 909,090 0.044 0 0 to 21,818,160 0.055
Previous diagnosis of BC         
   Previous BC 31   1000 0 to 909,090   22,000 0 to 21,818,160  
   No BC 43 0.361 390 0 to 50,000 0.191 6000 0 to 1,229,667 0.189
Parity         
   Parous 35   750 0 to 909,090   12,000 0 to 21,818,160  
   Non-parous 58 0.073 0 0 – 50,000 0.395 0 0 to 600,000 0.261
Breast feeding         
   Breast fed 31   1000 0 to 909,090   15,426 0 to 21,818,160  
   No breast feeding 57 0.024 0 0 to 50,000 0.091 0 0 to 600,000 0.057
BC during study         
   BC 20   6666 0 to 25,850   79,992 0 to 542,850  
   No BC 40 0.645 500 0 to 909,090 0.133 7688 0 to 21,818,160 0.261
Cytologic atypia         
   Mild atypia    5355 84 to 50,000   105,870 1920 to 1,229,667  
   Severe atypia    3591 1917 to 18,666 0.75 113,752 48,000 to 447,996 0.892
   Atypia (mild + severe) 0   4875 84 to 50,000   105,870 1920 to 1,229,667  
   No atypia 50 <0.001 14 0 to 909,090 <0.001 174 0 to 21,818,160 <0.001
  1. Cellularity is expressed both as cells/ml, to account for variations in the volume of DL collected, as well as total number of cells/specimen in order to permit comparisons between our results and other published studies. P1= Fisher's exact test; P2= Mann-Whitney test. BC, breast cancer; ICMD, inadequate cellular material for diagnosis; FY, ducts producing nipple aspirate fluid.