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Table 4 Effects of rapamycin plus CN-A on cell cycle regulatory genes

From: Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts

  Gene expression ratio
Gene name Rapamycin + CN-A Rapamycin CN-A
Cyclin A2 0.51 0.54 0.82
Cyclin B1 0.71 0.77 0.84
Cyclin B2 0.84 0.89 0.89
Cyclin D1 0.94 0.96 1
Cyclin D3 0.86 0.7 1.09
Cyclin E1 0.44 0.67 0.66
Cyclin E2 0.53 0.64 0.87
Cyclin G1 1.43 1.25 1.02
Cyclin G2 6.08 3.07 3.22
Cyclin-dependent kinase 2 (CDK2) 0.58 0.78 0.83
Cyclin-dependent kinase 4 (CDK4) 0.62 0.81 0.77
Cell division cycle 2 (CDC2) 0.62 0.7 0.85
P53 1.37 1.52 1.32
P21 (Cip1) 0.85 0.83 1.03
P27 (Kip1) 1.65 1.39 1.18
Retinoblastoma 1 (RB1) 1.08 1.09 1.04
Retinoblastoma-like 1 (p107) 0.53 0.67 0.87
Retinoblastoma-like 2 (p130) 1.96 2.18 1.07
E2F transcription factor 3 (E2F3) 0.42 0.86  
E2F transcription factor 5, p130-binding (E2F5) 0.96 1.21 0.81
E2F transcription factor 6 (E2F6) 0.62 0.70 0.65
  1. CN-A, cotylenin A.