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Table 2 Upregulated genes in MCF-7 cells after exposure to rapamycin plus CN-A for 12 hours

From: Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts

   Gene expression ratio
GenBank number Gene name Rapamycin + CN-A Rapamycin CN-A
NM_000358.1 Transforming growth factor-β-induced 68 kDa (TGFBI) 8.16 1.74 5.2
NM_001038.1 Sodium channel, nonvoltage-gated 1α(SCNN1A) 6.99 1.49 4.26
NM_002281.2 Keratin, hair, basic-1 (KRTHB1) 6.96 1.27 12.8a
NM_001197.3 BCL2-interacting killer (apoptosis-inducing; BIK) 6.76 2.37 3.59
NM_004354.1 Cyclin G2 (CCNG2) 6.08 3.07 3.22
NM_005310.1 Growth factor receptor-bound protein 7 (GRB7) 5.81 2.48 2.61
NM_020898.1 KIAA1536 protein (KIAA1536) 5.42 2.78 1.8
NM_030777.2 Solute carrier family 2, member 10 (SLC2A10) 5.09 1.53 2.51
NM_005727.2 Tetraspan 1 (TSPAN-1) 4.61 1.54 1.76
NM_024709.1 Hypothetical protein FLJ14146 (FLJ14146) 4.55 1.8 2.53
NM_014376.1 Cytoplasmic FMR1 interacting protein 2 (CYFIP2) 4.21 2.43 1.66
NM_017644.1 Hypothetical protein FLJ20059 (FLJ20059) 4.09 1.51 1.2
NM_002166.1 Inhibitor of DNA binding 2 (ID2) 4.03 1.23 2.93
NM_006813.1 Proline rich 2 (PROL2) 3.87 2.8 1.9
NM_002885.1 RAP1, GTPase activating protein 1 (RAP1GA1) 3.81 1.56 2.51
NM_000755.2 Carnitine acetyltransferase (CRAT) 3.79 1.75 2.45
NM_031477.2 Hypothetical protein MGC10500 (MGC10500) 3.72 2.18 2.29
NM_012257.2 HMG-box containing protein 1 (HBP1) 3.7 1.67 1.55
NM_020169.2 Latexin protein (LXN) 3.68 2.49 2.40
NM_014417.2 BCL2 binding component 3 (BBC3) 3.55 1.82 2.18
NM_024642.2 GalNAc-T12 (GALNT12) 3.49 1.49 2.53
NM_016162.1 Inhibitor of growth family, member 4 (ING4) 3.47 1.98 1.73
NM_017673.2 Chromosome 1 open reading frame 26 (C1orf26) 3.45 1.44 2.93
NM_014353.2 RAB26, member RAS oncogene family (RAB26) 3.42 2.40 1.49
NM_005178.2 B-cell CLL/lymphoma 3 (BCL3) 3.39 1.05 3.31
  1. aIncreased upper reliable levels. CN-A, cotylenin A.