Effects of rapamycin and CN-A on the growth of MCF-7 cells as xenografts. Mice were given a daily intraperitoneal injection of 100 ng rapamycin (black square, black circle) and/or subcutaneous injection of 100 μg of CN-A (black triangle, black circle) every other day. Values are expressed as mean ± standard deviation of 20 mice. Black diamond, untreated mice; white circle, mice treated with solvent alone. CN-A, cotylenin A; *, p < 0.05; **, p < 0.001.