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Table 3 Calculation of Z using prevention trial data

From: Tamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis

Risk reduction

Za

 

BCPT

MORE

50%

23.5%

26.6%

60%

20.1%

22.7%

70%

16.2%

18.2%

80%

11.6%

13.1%

90%

6.3%

7.1%

  1. aZ is the rate of transformation from ER+ to ER- tumors. BCPT, Breast Cancer Prevention Trial; MORE, Multiple Outcomes of Raloxifene.