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Table 1 Exposure to tamoxifen appears to affect the conditional likelihood of the estrogen receptor status of subsequent contralateral primary breast cancers

From: Tamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis

ER status of tumors

Tamoxifen treatment

First cancer

Second cancer

No

Yes

ER-

ER-

19 (70%)

7 (78%)

 

ER+

8 (30%)

2 (22%)

ER+

ER-

4 (11%)

17 (44%)

 

ER+

31 (89%)

22 (56%)

  1. Data were taken from the National Surgical Adjuvant Breast and Bowel Project trials B-18, B-22, and B-25 [5]. ER, estrogen receptor.