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Table 2 Top 33 dual regulated genes

From: The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells

GenBank ID

AR

PR

Description

 

MPA

DHT

MPA

P

 

NM_005627

67.53

51.80

23.33

29.48

Serum/glucocorticoid regulated kinase

AI985987

31.45

33.87

6.39

11.72

Sodium channel, nonvoltage-gated 1, gamma

AI492388

26.17

11.44

37.57

31.08

ti27d10.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE:2131699 3', mRNA sequence.

AV707102

11.91

11.13

4.23

4.04

Pyruvate dehydrogenase kinase, isoenzyme 4

NM_004117

11.10

9.08

3.15

3.21

FK506 binding protein 5

AL556438

10.88

11.23

4.77

3.14

TCDD-inducible poly(ADP-ribose) polymerase

AA404269

8.33

7.36

6.22

5.29

Prickle-like 1 (Drosophila)

AB018580

7.54

5.38

4.74

4.69

Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

NM_005461

6.82

11.65

15.98

15.80

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

NM_001993

6.76

6.39

20.32

12.77

Coagulation factor III (thromboplastin, tissue factor)

NM_001992

6.01

5.99

4.61

2.84

Coagulation factor II (thrombin) receptor

BE219979

5.82

8.07

12.62

12.49

Interleukin 20 receptor, alpha

NM_019018

5.06

4.63

8.18

8.43

Hypothetical protein FLJ11127

NM_006096

4.63

4.34

10.19

10.50

N-myc downstream regulated gene 1

NM_012429

4.42

4.95

4.06

3.76

SEC14-like 2 (S. cerevisiae)

W86302

4.22

3.96

2.58

2.68

FK506 binding protein 5

AF288571

4.07

3.95

2.91

3.38

Lymphoid enhancer-binding factor 1

AW135013

4.00

8.54

16.37

13.28

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

BF593382

3.71

3.53

2.16

2.27

Protein kinase, AMP-activated, beta 2 non-catalytic subunit

AF131840

3.61

4.13

3.87

3.14

SPRY domain-containing SOCS box protein SSB-1

AA721025

3.47

3.00

5.59

3.30

Homo sapiens transcribed sequence with moderate similarity to protein ref:NP_060265.1 (H.sapiens)

AI753747

3.32

3.23

2.46

2.22

FK506 binding protein 5

N73742

3.31

3.18

3.73

3.45

Homo sapiens cDNA FLJ42287 fis, clone TLIVE2005866

AA037766

3.27

2.81

3.17

2.56

Homo sapiens LOC374963 (LOC374963), mRNA

AL357503

3.17

4.55

8.33

8.02

Match: proteins: Tr:Q9UJ12 Tr:O43723 Tr:Q9VZN3

NM_004235

3.06

4.89

4.69

4.83

Kruppel-like factor 4 (gut)

BI668074

3.06

4.81

2.52

2.36

603295907F1 NIH_MGC_96 Homo sapiens cDNA

AL562398

2.82

2.24

2.12

2.14

AL562398 Homo sapiens NEUROBLASTOMA COT 25-NORMALIZED

BG150485

2.78

2.88

2.79

2.03

Solute carrier family 6 (neurotransmitter transporter, taurine), member 6

BF056282

2.77

2.43

2.33

2.18

Chromosome 9 open reading frame 52

BF514079

2.73

4.33

8.09

7.66

Kruppel-like factor 4 (gut)

  1. Shown are the top genes and their fold upregulation in Y-AR (AR+) and T47D (PR+) cells treated with physiologic concentrations of MPA and either DHT or progesterone. AR, androgen receptors; DHT, dihydrotestosterone; MPA, medroxyprogesterone acetate; P, progesterone; PR, progesterone receptor.