A common missense variant in BRCA2 predisposes to early onset breast cancer

Breast Cancer Research

Table 1 Frequencies of the BRCA2 C5972T variant allele in breast cancer patients and controls

Variant	Controls	Cases	Odds ratio	p-value	95% CI
All subjects
CC	2,630	3,039	1.0
CT	159	191	1.0	0.74	[0.8–1.3 ]
TT	2	11	4.8	0.02	[1.1–21.4]
CT+TT	161	202	1.1	0.45	[0.9–1.3 ]
Total	2,791	3,241
Cases under age 40 years
CC	2,630	598	1.0
CT	159	51	1.4	0.04	[1.0–2.0 ]
TT	2	1	2.2	0.46	[0.2–23.7]
CT+TT	161	52	1.4	0.03	[1.0–1.9 ]
Total	2,791	650
Cases 41+ years
CC	2,630	2,441	1.0
CT	159	140	0.9	0.68	[0.8–1.2 ]
TT	2	10	5.4	0.02	[1.2–24.6]
CT+TT	161	150	1.0	0.97	[0.8–1.3 ]
Total	2,791	2,591

ISSN: 1465-542X