Table 5 Combined XRCC1 and XPD genotypes and breast cancer risk among all and ever smoking women
From: XRCC1 and XPDgenetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study
All women | Ever actively smoking women | ||||||||
|---|---|---|---|---|---|---|---|---|---|
No of at risk genotypes | XRCC1-280 | XRCC1-399 | XPD-751 | Case/Control | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a | Case/Control | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a |
0 | Arg/Arg | Arg/Arg | Lys/Lys+ Lys/Gln | 145/159 | 1.0 | 1.0 | 23/46 | 1.0 | 1.0 |
1 | Arg/Arg | Arg/Arg | Gln/Gln | 32/44 | 0.80 (0.48–1.33) | 0.72 (0.42–1.25) | 8/12 | 1.33 (0.48–3.72) | 1.20 (0.37–3.86) |
1 | Arg/Arg | Arg/Gln+ Gln/Gln | Lys/Lys+ Lys/Gln | 172/170 | 1.11 (0.81–1.51) | 1.15 (0.83–1.60) | 43/48 | 1.79 (0.94–3.43) | 1.93 (0.93–4.05) |
1 | Arg/His+His/His | Arg/Arg | Lys/Lys+ Lys/Gln | 45/44 | 1.12 (0.70–1.80) | 1.19 (0.72–1.97) | 11/15 | 1.47 (0.58–3.70) | 1.94 (0.69–5.44) |
1 (any one at risk genotype) | - | - | - | 249/258 | 1.06 (0.80–1.41) | 1.09 (0.81–1.47) | 62/75 | 1.65 (0.91–3.02) | 1.80 (0.91–3.56) |
2 | Arg/Arg | Arg/Gln+ Gln/Gln | Gln/Gln | 46/32 | 1.58 (0.95–2.61) | 1.80 (1.05–3.08) | 19/5 | 7.60 (2.52–22.0) | 12.1 (3.52–41.5) |
2 | Arg/His+ His/His | Arg/Gln+ Gln/Gln | Lys/Lys+ Lys/Gln | 19/18 | 1.16 (0.59–2.29) | 1.28 (0.62–2.64) | 3/0 | - | - |
2 | Arg/His+ His/His | Arg/Arg | Gln/Gln | 13/9 | 1.58 (0.66–3.82) | 1.36 (0.52–3.59) | 3/2 | 3.00 (0.47–19.2) | 3.47 (0.44–27.1) |
2 (any two at risk genotypes) | - | - | - | 78/59 | 1.45 (0.97–2.18) | 1.54 (1.00–2.37) | 25/7 | 7.14 (2.69–19.0) | 10.7 (3.62–31.6) |
3 | Arg/His+His/His | Arg/Gln+ Gln/Gln | Gln/Gln | 4/1 | 4.39 (0.49–39.7) | 4.76 (0.48–47.8)b | 1/0 | - | - |