Table 3 Association between XRCC1 and XPD genotypes and breast cancer risk according to smoking habits
From: XRCC1 and XPDgenetic polymorphisms, smoking and breast cancer risk in a Finnish case-control study
Genotype | Never active or passive smoking | Only passive smoking | Active smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|
Cases (%) | Controls (%) | OR (95% CI)a | Cases (%) | Controls (%) | OR (95% CI)a | Cases (%) | Controls (%) | OR (95% CI)a | |
XRCC1-280 | |||||||||
Arg/Arg | 177 (84.7) | 154 (84.6) | 1.0 | 120 (79.5) | 140 (83.8) | 1.0 | 94 (83.9) | 111 (86.0) | 1.0 |
Arg/His+His/His | 32 (15.3) | 28 (15.4) | 1.09 (0.60–1.99) | 31 (20.5) | 27 (16.2) | 1.11 (0.59–2.08) | 18 (16.1) | 18 (14.0) | 1.41 (0.65–3.08) |
XRCC1-399 | |||||||||
Arg/Arg | 118 (56.5) | 89 (48.9) | 1.0 | 72 (47.7) | 91 (54.5) | 1.0 | 45 (40.5) | 75 (58.6) | 1.0 |
Arg/Gln | 76 (36.4) | 76 (41.8) | 0.83 (0.53–1.31) | 67 (44.4) | 66 (39.5) | 1.40 (0.84–2.32) | 49 (44.2) | 43 (33.6) | 2.14 (1.15–3.97) |
Gln/Gln | 15 (7.2) | 17 (9.3) | 0.73 (0.33–1.64) | 12 (7.9) | 10 (6.0) | 1.61 (0.61–4.23) | 17 (15.3) | 10 (7.8) | 3.27 (1.25–8.58)b |
Arg/Gln+Gln/Gln | 91 (43.5) | 93 (51.1) | 0.81 (0.53–1.25) | 79 (52.3) | 76 (45.5) | 1.42 (0.87–2.32) | 66 (59.5) | 53 (41.4) | 2.33 (1.30–4.19)c |
XPD-751 | |||||||||
Lys/Lys | 66 (31.6) | 58 (31.9) | 1.0 | 40 (26.3) | 56 (33.3) | 1.0 | 40 (35.7) | 40 (31.0) | 1.0 |
Lys/Gln | 109 (52.2) | 91 (50.0) | 1.03 (0.63–1.66) | 83 (54.6) | 77 (45.8) | 1.35 (0.78–2.34) | 40 (35.7) | 77 (45.8) | 0.68 (0.35–1.33) |
Gln/Gln | 34 (16.3) | 33 (18.1) | 0.78 (0.40–1.49) | 29 (19.1) | 35 (20.8) | 0.84 (0.41–1.69) | 32 (28.6) | 35 (20.8) | 1.96 (0.89–4.32) |
Lys/Lys+Lys/Gln | 175 (83.7) | 149 (81.9) | 1.0 | 123 (80.9) | 133 (79.2) | 1.0 | 80 (71.4) | 109 (84.5) | 1.0 |
Gln/Gln | 34 (16.3) | 33 (18.1) | 0.77 (0.43–1.39) | 29 (19.1) | 35 (20.8) | 0.70 (0.38–1.29) | 32 (28.6) | 20 (15.5) | 2.52 (1.27–5.03)d |