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Table 5 Main biological functions among the present 64-gene set and the 70-gene set from the van't Veer study

From: Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

Biological function

64-gene set (present study)

70-gene set (van't Veer and colleagues)

DNA replication/transcription/nucleosome assembly

IGF1, RRM2×2, TOP2A

ORC6L, MCM6, RFC4

 

PFS2, CENPF, HOXA5, CBFA2T1, SETBP1, UHRF1, MKI67, HIST1H2BG, H2AFZ

KIAA1442, CENPA

Cell cycle/proliferation/growth

CDKN1C, PTN, CDC2×2,

EXT1, HEC, PRC1, NUSAP1 (LOC51203), MCM6, Cyclin E2, TGFB3, FLT1, FGF18, ECT2, GMPS, IGFBP5 × 2, ESM1, WISP1

 

BUB1B, ESPL1, PRC1, TOP2A, NUSAP1 (LOC51203), CENPF, IGF1, RHOJ, UHRF1,PDGFD, CBFA2T1, NOV

 

Apoptosis

ESPL1

FLT1

Cell adhesion/motility/invasion/metastasis

SLIT2, COL14A1, FLRT2, MFAP4, CLDN7, IGF1, RHOJ

WISP1, FGF18, MMP9

Angiogenesis

PTN

FLT1

Signal transduction

IGF1, RHOJ,

EXT1, GNAZ, GFBP5, CFFM4, FGF18, NMU, RAB6B, PK428, PK428 MP1, WISP1, DKFZP564D0462 (GPR126)

 

PTN, DNM1, GPR56