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Table 1 Putative ESEs in BRCA1

From: Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1gene with missense sequence changes and in-frame deletions, but not polymorphisms

Exon

Length (nt)

Predicted SF2/ASF ESEs

Predicted SC35 ESEs

Predicted SRp40 ESEs

Predicted SRp55 ESEs

Total predicted ESEs

Nucleotides mapping to predicted ESEs

ESEs as % of exon

2

80

0

0

1

1

2

13

16.250

3

54

0

0

2

1

3

18

33.333

5

78

2

0

4

2

8

41

52.564

6

89

1

0

3

0

4

22

24.719

7

140

2

3

4

3

12

57

40.714

8

106

4

3

3

1

11

51

48.113

9

46

1

0

0

0

1

7

15.217

10

77

2

1

3

0

6

28

36.364

11

3426 (250)

90 (7)

48 (4)

93 (7)

34 (2)

265 (20)

1405 (106)

41.010 (42.400)

12

89

3

1

2

2

8

44

49.438

13

172

4

3

4

3

14

80

46.512

14

127

4

2

7

2

15

66

51.969

15

191

7

2

6

3

18

105

54.974

16

311 (250)

5 (4)

9 (6)

10 (8)

3 (1)

27 (19)

143 (110)

45.981 (44.000)

17

88

3

4

2

2

11

49

55.682

18

78

3

1

1

1

6

32

41.026

19

41

0

0

0

0

0

0

0.000

20

84

2

4

4

0

10

38

45.238

21

55

1

1

2

0

4

23

41.818

22

74

2

1

2

3

8

40

54.054

23

61

3

3

2

1

9

37

60.656

24

125

6

6

7

3

22

89

71.200

Total

5592 (2355)

145 (61)

92 (45)

162 (74)

65 (31)

464 (211)

2388 (1056)

42.704 (44.841)

  1. Numbers in parentheses refer to those sequences within 125 nucleotides (nt) of the exon end. ESE, exonic splicing enhancer.