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Figure 1 | Breast Cancer Research

Figure 1

From: Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1gene with missense sequence changes and in-frame deletions, but not polymorphisms

Figure 1

Shared and conserved predicted ESEs in the human and mouse BRCA1 genes. The BRCA1 open reading frame (ORF) divided into exons is shown to scale, with shorter analyzed fragments of exons 11 and 16. Conserved exonic splicing enhancers (ESEs) are shown on the top of the ORF, with shared ESEs shown on the bottom. Overlapping ESE motifs are staggered. SF2/ASF ESE motifs are shown in red, with SC35 in blue, SRp40 in green and SRp55 in yellow, also to scale. Cryptic splice sites (CSSs) in exons 5 and 11 are marked. Only the sequence within 125 nucleotides (nt) of exonic splice donor and acceptor consensus sequences has been analysed. Conserved ESEs are those sequences that were identical in human, primates, mouse cow, dog and opossum Brca1. Shared ESEs are those sequences for which ESEfinder predicted a binding site for the same arginine-serine rich protein (SR protein) to the same exon position but the motif sequence was not the same between species.

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