Table 2 Effect of antisense Bcl-xL oligodeoxynucleotides on chemosensitivity in BT-474, ZR-75-1, and MDA-MB-231 breast cancer cells
From: Targeted therapy against Bcl-2-related proteins in breast cancer cells
Cell line | Drug | IC50 (μM)a | Fold increase in AS Bcl-xL | ||
|---|---|---|---|---|---|
| Â | Â | Control | Sense Bcl-xLb | AS Bcl-xLb | Â |
BT-474 | AS Bcl-xL | 4.0 | -- | -- | -- |
| Â | DOX | 1.0 | 0.92 | 0.68 | 1.5 |
| Â | MMC | 1.4 | 1.32 | 0.88 | 1.6 |
| Â | TXL | 2.4 | 2.2 | 1.34 | 1.8 |
| Â | TXT | 0.54 | 0.51 | 0.26 | 2.1 |
ZR-75-1 | AS Bcl-xL | 1.8 | -- | -- | -- |
| Â | DOX | 0.54 | 0.51 | 0.71 | 1.3 |
| Â | MMC | 0.84 | 0.79 | 0.39 | 2.2 |
| Â | TXL | 1.9 | 1.8 | 1.2 | 1.6 |
| Â | TXT | 3.1 | 3.0 | 1.7 | 1.8 |
MDA-MB-231 | AS Bcl-xL | 2.2 | -- | -- | -- |
| Â | DOX | 0.19 | 0.18 | 0.076 | 2.5 |
| Â | MMC | 0.68 | 0.65 | 0.19 | 3.6 |
| Â | TXL | 2.8 | 2.6 | 0.96 | 2.9 |
| Â | TXT | 1.2 | 1.1 | 0.62 | 1.9 |