Table 1 Effect of antisense Bcl-2 oligodeoxynucleotides on chemosensitivity in BT-474, ZR-75-1, and MDA-MB-231 breast cancer cells
From: Targeted therapy against Bcl-2-related proteins in breast cancer cells
Cell line | Drug | IC50 (μM)a | Fold increase in AS Bcl-2 | ||
|---|---|---|---|---|---|
| Â | Â | Control | Sense Bcl-2b | AS Bcl-2b | Â |
BT-474 | AS Bcl-2 | 3.6 | -- | -- | -- |
| Â | DOX | 1.0 | 0.97 | 0.12 | 8.3 |
| Â | MMC | 1.4 | 1.3 | 0.81 | 1.7 |
| Â | TXL | 2.4 | 2.3 | 0.29 | 8.3 |
| Â | TXT | 0.54 | 0.50 | 0.054 | 10.0 |
ZR-75-1 | AS Bcl-2 | 1.8 | -- | -- | -- |
| Â | DOX | 0.54 | 0.48 | 0.075 | 7.2 |
| Â | MMC | 0.84 | 0.77 | 0.33 | 2.5 |
| Â | TXL | 1.9 | 1.7 | 0.62 | 3.1 |
| Â | TXT | 3.1 | 2.8 | 0.80 | 3.9 |
MDA-MB-231 | AS Bcl-2 | 5.2 | -- | -- | -- |
| Â | DOX | 0.19 | 0.17 | 0.032 | 5.9 |
| Â | MMC | 0.68 | 0.62 | 0.22 | 3.1 |
| Â | TXL | 2.8 | 2.6 | 0.43 | 6.5 |
| Â | TXT | 1.2 | 1.1 | 0.23 | 5.2 |