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Figure 4 | Breast Cancer Research

Figure 4

From: Targeted therapy against Bcl-2-related proteins in breast cancer cells

Figure 4

Changes in chemosensitivity of MDA-MB-453 cells to anticancer drugs after transfection with bcl-2 gene. (a) Expression levels of Bcl-2 and Bcl-xL were examined in MDA-MB-453 cells by Western blot analysis. MDA-MB-453 cells transfected with the bcl-2 gene expressed greater levels of Bcl-2 protein; however, similar levels of Bcl-xL protein were observed. (b) Cells treated with 0.15 μM doxorubicin (DOX) or with 2.0 μM mitomycin C (MMC), paclitaxel (TXL) or docetaxel (TXT). After 48 hours, cells were stained with trypan blue and counted. Each point represents the mean of triplicate experiments. Error bars indicate SD. *, P < 0.05, Student's t-test. The data presented are from three independent experiments.

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