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Table 1 Demographic and tumor characteristics of breast cancer cases overall and by ER-α A908G mutation status

From: The estrogen receptor-α A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study

Characteristic

Total cases (N = 653)

Mutation positive (N = 37)

Mutation negative (N = 616)

ORa

95% CI

P

 

n (%)

n (%)

n (%)

   

Age (years)

      

   50+

265 (40.6)

19 (51.4)

246 (40.0)

1.00

  

   <50

388 (59.4)

18 (48.6)

370 (60.0)

1.65

0.41–6.64

0.48

Race

      

   White

398 (60.9)

25 (67.6)

371 (60.2)

1.00

  

   African American

257 (39.1)

12 (32.4)

245 (39.8)

0.70

0.34–1.42

0.32

Menopausal status

      

   Postmenopausal

317 (48.5)

22 (59.5)

295 (47.9)

1.00

  

   Premenopausal

336 (51.5)

15 (40.5)

321 (52.1)

1.14

0.39–3.35

0.82

Stageb

      

   I

239 (39.3)

11 (35.5)

228 (39.5)

1.00

  

   II

298 (49.0)

16 (51.7)

282 (48.9)

1.35

0.61–3.00

0.46

   III, IV

71 (11.7)

4 (12.8)

67 (11.6)

1.67

0.50–5.64

0.41

Primary tumor size

      

   ≤ 2 cm

327 (52.3)

14 (42.4)

313 (52.9)

1.00

  

   >2 cm

298 (47.7)

19 (57.6)

279 (47.1)

1.81

0.87–3.74

0.11

Lymph node status

      

   Negative

377 (60.5)

18 (54.5)

359 (60.8)

1.00

  

   Positive

246 (39.5)

15 (45.5)

231 (39.2)

1.46

0.71–2.99

0.30

ER expression

      

   ER+

370 (58.8)

20 (58.8)

350 (58.8)

1.00

  

   ER-

259 (41.2)

14 (41.2)

245 (41.2)

1.24

0.60–2.56

0.57

Mitotic indexc

      

   ≤ 10

364 (56.4)

25 (67.6)

339 (55.8)

1.00

  

   >10

281 (43.6)

12 (32.4)

269 (44.2)

0.74

0.35–1.54

0.42

Histologic grade

      

   Well to moderately differentiated

221 (34.1)

11 (29.7)

210 (34.3)

1.00

  

   Poorly differentiated

428 (65.9)

26 (70.3)

402 (65.7)

1.43

0.69–2.99

0.34

Nuclear grade

      

   Slight to moderate pleomorphism

375 (57.7)

20 (54.1)

355 (57.9)

1.00

  

   Marked pleomorphism

275 (42.3)

17 (45.9)

258 (42.1)

1.48

0.74–2.97

0.27

Combined tumor graded

      

   I

162 (25.2)

6 (16.2)

156 (25.7)

1.00

  

   II

198 (30.7)

18 (48.7)

180 (29.7)

2.83

1.09–7.34

0.03

   III

284 (44.1)

13 (35.1)

271 (44.6)

1.65

0.60–4.59

0.33

Histologic type(s)

      

   Ductal NOSe

513 (78.6)

27 (73.0)

486 (78.9)

1.00

  

   Ductal variantsf

21 (3.2)

1 (2.7)

20 (3.2)

0.69

0.09–5.42

0.72

   Lobularg

58 (8.9)

2 (5.4)

56 (9.1)

0.57

0.13–2.50

0.46

   Mixed lobular/ductal

61 (9.3)

7 (18.9)

54 (8.8)

2.10

0.86–5.12

0.10

  1. aOdds ratios adjusted for age and race. bAccording to the American Joint Committee on Cancer breast tumor staging guidelines. cPer 10 high power fields. dComposite score based on mitotic index, histologic grade and nuclear grade. eDuctal NOS (not otherwise specified), n = 462; medullary, n = 4; neuroendocrine, n = 2; poorly differentiated, n = 13; metaplastic, n = 5; other mixed, n = 27. fDuctal variants include mucinous (n = 11), tubular (n = 2), papillary (n = 4), and other (n = 4). gLobular, classic and/or variant. CI, confidence interval; ER, estrogen receptor.
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Breast Cancer Research

ISSN: 1465-542X

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