Table 3 Association of hypoxia-inducible factor 1 alpha (HIF-1α) with its downstream effectors, microvessel counts and proliferation markers in stroma of fibroepithelial tumors

p53

   <10%

45

15

0.003

   ≥10%

1

6

Vascular endothelial growth factor

   Weak

33

10

0.098

   Strong

13

11

Hot-spot microvessel count

   <71

25

5

0.031

   ≥71

20

15

Global microvessel count

   <86

27

5

0.015

   ≥86

18

15

Carbonic anhydrase IX

   Negative

45

19

0.098

   Positive

0

2

Ki67

   <10%

42

7

<0.001

   ≥10%

4

14

Mitotic activity index

   <10

43

8

<0.001

   ≥10

3

13