Table 2 Differences in expression of hypoxia-related proteins, microvasculature and proliferation between different grades of phyllodes tumors

Stroma

   HIF-1α

5 (31%)

3 (38%)

11 (100%)

0.001

   CAIX

0 (0%)

0 (0%)

2 (18%)

0.090

   VEGF

5 (31%)

3 (38%)

9 (82%)

0.016

   Ki67

1 (6%)

5 (63%)

11 (100%)

<0.001

   Hot-spot microvessel count

9/16 (56%)

2 (25%)

11 (100%)

0.003

   Global microvessel count

8/16 (50%)

2 (25%)

11 (100%)

0.002

   p53

1/18(6%)

1/8(13%)

5/11(46%)

0.025

Epithelium

   HIF-1α

7/17 (42%)

2 (25%)

6/10 (60%)

0.323

   CAIX

5 (32%)

1/7 (14%)

3/10 (30%)

0.735

   VEGF

12 (67%)

5 (63%)

5/10 (50%)

0.684

   Ki67

1 (6%)

0 (0%)

1/10 (10%)

0.655

   p53

0(0%)

0(0%)

0(0%)

-