Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Breast Cancer Research

Table 5 Weight change and subsequent cancer risk: subjects^a stratified by BRCA mutation and parity

Weight change between age 18 and 30 years	Cases (number)	Controls (number)	OR^c (95% CI)	P	P for trend^d
In BRCA1 mutation carriers
Loss of <10 to gain of ≤ 10 pounds^b	188	189	1 (referent)
Gain of >10 pounds
Parity = 0	24	28	0.88 (0.50–1.55)	0.66
Parity = 1	26	27	0.94 (0.52–1.72)	0.85
Parity ≥ 2	117	84	1.44 (1.01–2.04)	0.04	0.16
Parity unknown	2	4
In BRCA2 mutation carriers
Loss of <10 to gain of ≤ 10 pounds^b	67	65	1 (referent)
Gain of >10 pounds
Parity = 0	6	4	1.44 (0.40–5.13)	0.58
Parity = 1	7	6	1.10 (0.33–3.72)	0.87
Parity ≥ 2	18	22	0.73 (0.33–1.64)	0.45	0.31
Parity unknown	0	0

^aWhose cancer was diagnosed when they were 30 to 39 years old. ^bA negative number indicates weight loss. ^cAll ORs were derived using univariate conditional logistic regression. ^dExcludes subjects in the weight-gain ≤ -10 group.

ISSN: 1465-542X