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Table 5 Weight change and subsequent cancer risk: subjectsa stratified by BRCA mutation and parity

From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Weight change between age 18 and 30 years Cases (number) Controls (number) ORc (95% CI) P P for trendd
In BRCA1 mutation carriers      
   Loss of <10 to gain of ≤ 10 poundsb 188 189 1 (referent)   
   Gain of >10 pounds      
Parity = 0 24 28 0.88 (0.50–1.55) 0.66  
Parity = 1 26 27 0.94 (0.52–1.72) 0.85  
Parity ≥ 2 117 84 1.44 (1.01–2.04) 0.04 0.16
Parity unknown 2 4    
In BRCA2 mutation carriers      
   Loss of <10 to gain of ≤ 10 poundsb 67 65 1 (referent)   
   Gain of >10 pounds      
Parity = 0 6 4 1.44 (0.40–5.13) 0.58  
Parity = 1 7 6 1.10 (0.33–3.72) 0.87  
Parity ≥ 2 18 22 0.73 (0.33–1.64) 0.45 0.31
Parity unknown 0 0    
  1. aWhose cancer was diagnosed when they were 30 to 39 years old. bA negative number indicates weight loss. cAll ORs were derived using univariate conditional logistic regression. dExcludes subjects in the weight-gain ≤ -10 group.