From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers
Weight change between age 18 and 30 years | Cases (n) | Controls (n) | ORa (95% CI) | P | P for trend |
---|---|---|---|---|---|
In BRCA1 mutation carriers | 370 | 370 | Â | Â | Â |
   Loss of at least 10 pounds | 13 | 38 | 0.35 (0.18–0.67) | 0.002 |  |
   Loss of <10 to gain of ≤ 10 poundsd | 188 | 189 | 1 (referent) |  |  |
   Gain of 10 to ≤ 20 pounds | 93 | 72 | 1.29 (0.91–1.83) | 0.15 |  |
   Gain of >20 pounds | 76 | 71 | 1.09 (0.73–1.62) | 0.67 | 0.34 |
In BRCA2 mutation carriers | 108 | 108 | Â | Â | Â |
   Loss of at least 10 pounds | 10 | 11 | 0.88 (0.35–2.23) | 0.78 |  |
   Loss of <10 to gain of ≤ 10 poundsd | 67 | 65 | 1 (referent) |  |  |
   Gain of 10 to ≤ 20 pounds | 19 | 17 | 1.08 (0.50–2.35) | 0.84 |  |
Gain of >20 pounds | 12 | 15 | 0.77 (0.33–1.81) | 0.55 | 0.70 |