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Table 4 Weight change and subsequent cancer risk: subjects stratified by their BRCA mutation

From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Weight change between age 18 and 30 years Cases (n) Controls (n) ORa (95% CI) P P for trend
In BRCA1 mutation carriers 370 370    
   Loss of at least 10 pounds 13 38 0.35 (0.18–0.67) 0.002  
   Loss of <10 to gain of ≤ 10 poundsd 188 189 1 (referent)   
   Gain of 10 to ≤ 20 pounds 93 72 1.29 (0.91–1.83) 0.15  
   Gain of >20 pounds 76 71 1.09 (0.73–1.62) 0.67 0.34
In BRCA2 mutation carriers 108 108    
   Loss of at least 10 pounds 10 11 0.88 (0.35–2.23) 0.78  
   Loss of <10 to gain of ≤ 10 poundsd 67 65 1 (referent)   
   Gain of 10 to ≤ 20 pounds 19 17 1.08 (0.50–2.35) 0.84  
Gain of >20 pounds 12 15 0.77 (0.33–1.81) 0.55 0.70
  1. Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (matched control subjects) receive a diagnosis of breast cancer at age 30 to 39 years. aAll odds ratios (ORs) were derived using univariate conditional logistic regression. CI, confidence interval.