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Table 4 Weight change and subsequent cancer risk: subjects stratified by their BRCA mutation

From: Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Weight change between age 18 and 30 years

Cases (n)

Controls (n)

ORa (95% CI)

P

P for trend

In BRCA1 mutation carriers

370

370

   

   Loss of at least 10 pounds

13

38

0.35 (0.18–0.67)

0.002

 

   Loss of <10 to gain of ≤ 10 poundsd

188

189

1 (referent)

  

   Gain of 10 to ≤ 20 pounds

93

72

1.29 (0.91–1.83)

0.15

 

   Gain of >20 pounds

76

71

1.09 (0.73–1.62)

0.67

0.34

In BRCA2 mutation carriers

108

108

   

   Loss of at least 10 pounds

10

11

0.88 (0.35–2.23)

0.78

 

   Loss of <10 to gain of ≤ 10 poundsd

67

65

1 (referent)

  

   Gain of 10 to ≤ 20 pounds

19

17

1.08 (0.50–2.35)

0.84

 

Gain of >20 pounds

12

15

0.77 (0.33–1.81)

0.55

0.70

  1. Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (matched control subjects) receive a diagnosis of breast cancer at age 30 to 39 years. aAll odds ratios (ORs) were derived using univariate conditional logistic regression. CI, confidence interval.